ArticleJournal of muscle research and cell motility1996
Myosin-based cortical tension in Dictyostelium resolved into heavy and light chain-regulated components.
Article in Journal of muscle research and cell motility, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) α-kinase domain apoenzyme reveals a novel autoinhibited conformation.Scientific reports · 2016Article
- Modeling the Mechanosensitivity of Neutrophils Passing through a Narrow Channel.Biophysical journal · 2015Article
- Myosin heavy chain kinases play essential roles in Ca2+, but not cAMP, chemotaxis and the natural aggregation of Dictyostelium discoideum.Journal of cell science · 2012Article
- Cytokinesis mechanics and mechanosensing.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis.Molecular biology of the cell · 2010Article
- How a cell crawls and the role of cortical myosin II.Eukaryotic cell · 2009Article
- The effects of extracellular calcium on motility, pseudopod and uropod formation, chemotaxis, and the cortical localization of myosin II in Dictyostelium discoideum.Cell motility and the cytoskeleton · 2009Article
- Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.Development (Cambridge, England) · 2009Article
- Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB.Developmental biology · 2009Article
- Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.The Journal of cell biology · 2008Article
- A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.Molecular biology of the cell · 2005Article
- Signaling pathways regulating Dictyostelium myosin II.Journal of muscle research and cell motility · 2002Review
- Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins.The EMBO journal · 2001Article
- How well can an amoeba climb?Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The internal phosphodiesterase RegA is essential for the suppression of lateral pseudopods during Dictyostelium chemotaxis.Molecular biology of the cell · 2000Article
- Myosin I contributes to the generation of resting cortical tension.Biophysical journal · 1999Article
- Unconventional myosins at the crossroad of signal transduction and cytoskeleton remodeling.Protoplasma · 1999Article
- MLCK-A, an unconventional myosin light chain kinase from Dictyostelium, is activated by a cGMP-dependent pathway.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cortical tension in most nonmuscle cells is due largely to force production by conventional myosin (myosin II) assembled into the cytoskeleton. Cytoskeletal contraction in smooth muscle and nonmuscle cells is influenced by the degree of myosin filament assembly, and by activation of myosin motor function via regulatory light chain phosphorylation. Recombinant Dictyostelium discoideum cell lines have been generated bearing altered myosin heavy chains, resulting in either constitutive motor function or constitutive assembly into the cytoskeleton. Analysis of these cells allowed stiffening responses to agonists, measured on single cells, to be resolved into an regulatory light chain-mediated component reflecting activation of motor function, and a myosin heavy chain phosphorylation-regulated component reflecting assembly of filaments into the cytoskeleton. These two components can account for all of the cortical stiffening response seen during tested in vivo contractile events.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.