ReviewPharmaceutical research1996
Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution.
Review in Pharmaceutical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Polymeric Nanocarriers with pH-Dependent Release for Tumor-Specific Delivery.Recent advances in drug delivery and formulation · 2026Review
- Electroanalysis of Ibuprofen and Its Interaction with Bovine Serum Albumin.Molecules (Basel, Switzerland) · 2022Article
- L-Serine-Modified Poly-L-Lysine as a Biodegradable Kidney-Targeted Drug Carrier for the Efficient Radionuclide Therapy of Renal Cell Carcinoma.Pharmaceutics · 2022Article
- Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems.Macromolecules · 2022Review
- Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis.Molecules (Basel, Switzerland) · 2021Review
- Antibody screening using a human iPSC-based blood-brain barrier model identifies antibodies that accumulate in the CNS.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Recent trends in protein and peptide-based biomaterials for advanced drug delivery.Advanced drug delivery reviews · 2020Review
- l-Cysteine and l-Serine Modified Dendrimer with Multiple Reduced Thiols as a Kidney-Targeting Reactive Oxygen Species Scavenger to Prevent Renal Ischemia/Reperfusion Injury.Pharmaceutics · 2018Article
- Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury.Theranostics · 2017Article
- Design and pharmacokinetical aspects for the use of inorganic nanoparticles in radiomedicine.The British journal of radiology · 2016Review
- Molecular Design of Bisphosphonate-Modified Proteins for Efficient Bone Targeting In Vivo.PloS one · 2015Article
- Hydroxyethyl starch as an effective methotrexate carrier in anticancer therapy.Pharmacology research & perspectives · 2014Article
- Microfluidics-assisted in vitro drug screening and carrier production.Advanced drug delivery reviews · 2013Review
- Brushed block copolymer micelles with pH-sensitive pendant groups for controlled drug delivery.Pharmaceutical research · 2013Article
- Organized polysaccharide fibers as stable drug carriers.Carbohydrate polymers · 2013Article
- Hydrocolloid-based nutraceutical delivery systems.Food & function · 2012Article
- Block copolymer micelles for controlled delivery of glycolytic enzyme inhibitors.Pharmaceutical research · 2012Article
- EphA2 targeting peptide tethered bioreducible poly(cystamine bisacrylamide-diamino hexane) for the delivery of therapeutic pCMV-RAE-1γ to pancreatic islets.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Structure based antibody-like peptidomimetics.Pharmaceuticals (Basel, Switzerland) · 2012Article
- Detoxifying antitumoral drugs via nanoconjugation: the case of gold nanoparticles and cisplatin.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review article describes the current status and future perspectives of site-specific drug delivery by means of macromolecular carrier systems. Basic aspects and recent advances of targeted delivery of 1) conventional drugs, 2) protein drugs, and 3) gene medicines including antisense oligonucleotides and plasmid DNA, are reviewed from a pharmacokinetic perspective. Successful in vivo application of macromolecular carrier systems requires pharmacokinetic considerations at whole body, organ, cellular and subcellular levels. The integration of simultaneous research progress in the multidisciplinary fields such as biochemistry, cell and molecular biology, pharmacology, and pharmacokinetics will accelerate the emergence of marketed drugs with macromolecular carrier systems.
Indexed as
Identifiers
8792417What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.