ArticleProceedings of the National Academy of Sciences of the United States of America1996
Quantal release at a neuronal nicotinic synapse from rat adrenal gland.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.Cellular and molecular life sciences : CMLS · 2024Article
- Synaptotagmin-7 facilitates acetylcholine release in splanchnic nerve-chromaffin cell synapses during nerve activity.Neuroscience letters · 2023Article
- New insights about non-neurogenic excitability revealed by MEA recordings from rat adrenal chromaffin cells.Pflugers Archiv : European journal of physiology · 2023Article
- Calcium Imaging and Amperometric Recording in Cultured Chromaffin Cells and Adrenal Slices from Normotensive, Wistar Kyoto Rats and Spontaneously Hypertensive Rats.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ.The Journal of physiology · 2021Article
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- Muscarinic receptors in adrenal chromaffin cells: physiological role and regulation of ion channels.Pflugers Archiv : European journal of physiology · 2018Review
- GABA Signaling and Neuroactive Steroids in Adrenal Medullary Chromaffin Cells.Frontiers in cellular neuroscience · 2016Review
- Paracrine role of GABA in adrenal chromaffin cells.Cellular and molecular neurobiology · 2010Review
- Developmental and stress-induced remodeling of cell–cell communication in the adrenal medullary tissue.Cellular and molecular neurobiology · 2010Review
- The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open.British journal of pharmacology · 2010Article
- Functional characterization of alpha9-containing cholinergic nicotinic receptors in the rat adrenal medulla: implication in stress-induced functional plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Agrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesis.The Journal of cell biology · 2005Article
- Modeling of stimulation-secretion coupling in a chromaffin cell.Pflugers Archiv : European journal of physiology · 2004Article
- Wavelet analysis of nonstationary fluctuations of Monte Carlo-simulated excitatory postsynaptic currents.Biophysical journal · 2003Article
- Evidence for long-lasting cholinergic control of gap junctional communication between adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Gap junctions mediate electrical signaling and ensuing cytosolic Ca2+ increases between chromaffin cells in adrenal slices: A role in catecholamine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuronal nicotinic synapse in tissue slices of the adrenal medulla was studied with whole-cell patch-clamp. Excitatory postsynaptic currents (EPSCs) were evoked by local field stimulation or occurred spontaneously especially when external [K+] was increased. EPSCs were carried by channels sharing biophysical and pharmacological properties of neuronal-type nicotinic receptors (nAChRs). A single-channel conductance (gamma) of 43-45 pS was found from nonstationary variance analysis of EPSCs. Spontaneous EPSCs were tetrodotoxin-insensitive and Ca(2+)-dependent and occurred in burst-like clusters. Quantal analysis of spontaneous EPSCs gave a quantal size of 20 pA and amplitude histograms were well described by binomial models with low values of quantal content, consistent with a small number of spontaneously active release sites. However, rare large amplitude EPSCs suggest that the total number of sites is higher and that extrajunctional receptors are involved. Our estimates of quantal content and size at the chromaffin cell neuronal nicotinic synapse may be useful in characterizing central neuronal-type nicotinic receptor-mediated cholinergic synaptic transmission.
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