ArticleProceedings of the National Academy of Sciences of the United States of America1996
Subcellular localization of gamma-aminobutyric acid type A receptors is determined by receptor beta subunits.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 141 citations in OpenAlex.
- The grand challenge in cellular neurophysiology.Frontiers in cellular neuroscience · 2026Article
- Massive Activation of GABABiomolecules · 2025Review
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- GABAFrontiers in cellular neuroscience · 2024Article
- Recruitment of Plasma Membrane GABA-A Receptors by Submembranous Gephyrin/Collybistin Clusters.Cellular and molecular neurobiology · 2022Article
- Physiological Role of ATPase for GABAInternational journal of molecular sciences · 2022Article
- Non-Neuronal Transmitter Systems in Bacteria, Non-Nervous Eukaryotes, and Invertebrate Embryos.Biomolecules · 2022Review
- Structural determinants and regulation of spontaneous activity in GABANature communications · 2021Article
- Intricacies of GABAInternational journal of molecular sciences · 2021Review
- GABAFrontiers in cellular neuroscience · 2020Article
- Mechanisms of GABAScientific reports · 2019Article
- Cell surface expression of homomeric GABAThe Journal of biological chemistry · 2018Article
- Article
- Article
- γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.The Journal of biological chemistry · 2016Article
- Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.The Journal of biological chemistry · 2016Article
- Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.BMC neuroscience · 2015Article
- Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.Journal of visualized experiments : JoVE · 2014Article
- Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions.Psychopharmacology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
gamma-aminobutyric acid type A (GABAA) receptors are the major sites of fast synaptic inhibition in the brain. They are constructed from four subunit classes with multiple members: alpha (1-6), beta (1-4), gamma (1-4), and delta (1). The contribution of subunit diversity in determining receptor subcellular targeting was examined in polarized Madin-Darby canine kidney (MDCK) cells. Significant detection of cell surface homomeric receptor expression by a combination of both immunological and electrophysiological methodologies was only found for the beta 3 subunit. Expression of alpha/beta binary combinations resulted in a nonpolarized distribution for alpha 1 beta 1 complexes, but specific basolateral targeting of both alpha 1 beta 2 and alpha 1 beta 3 complexes. The polarized distribution of these alpha/beta complexes was unaffected by the presence of the gamma 2S subunit. Interestingly, delivery of receptors containing the beta 3 subunit to the basolateral domain occurs via the apical surface. These results show that beta subunits can selectively target GABAA receptors to distinct cellular locations. Changes in the spatial and temporal expression of beta-subunit isoforms may therefore provide a mechanism for relocating GABAA receptor function between distinct neuronal domains. Given the critical role of these receptors in mediating synaptic inhibition, the contribution of different beta subunits in GABAA receptor function, may have implications in neuronal development and for receptor localization/clustering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.