ArticleProceedings of the National Academy of Sciences of the United States of America1996
Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm).
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 146 citations in OpenAlex.
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- Untangling the wires: development of sparse, distributed connectivity in the mushroom body calyx.Cell and tissue research · 2021Review
- Genetic background impacts the timing of synaptonemal complex breakdown in Drosophila melanogaster.Chromosoma · 2020Article
- Overexpression of isoform B of Dgp-1 gene enhances locomotor activity in senescent Drosophila males and under heat stress.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Control of basal autophagy rate by vacuolar peduncle.PloS one · 2019Article
- Fishing forward and reverse: Advances in zebrafish phenomics.Mechanisms of development · 2018Review
- Environmental effects onThe Journal of experimental biology · 2018Article
- Beyond Royalactin and a master inducer explanation of phenotypic plasticity in honey bees.Communications biology · 2018Review
- How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects.PLoS genetics · 2017Article
- Mcm3 replicative helicase mutation impairs neuroblast proliferation and memory in Drosophila.Genes, brain, and behavior · 2016Article
- Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex.G3 (Bethesda, Md.) · 2016Article
- Synapsin is required to "boost" memory strength for highly salient events.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Memory Elicited by Courtship Conditioning Requires Mushroom Body Neuronal Subsets Similar to Those Utilized in Appetitive Memory.PloS one · 2016Article
- Article
- From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment.Frontiers in psychiatry · 2015Review
- Spindle orientation: what if it goes wrong?Seminars in cell & developmental biology · 2014Review
- Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution.Trends in genetics : TIG · 2013Review
- Probing mechanisms that underlie human neurodegenerative diseases in Drosophila.Annual review of genetics · 2012Review
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Mutations in 12 genes regulating Drosophila melanogaster mushroom body (MB) development were each studied in two genetic backgrounds. In all cases, brain structure was qualitatively or quantitatively different after replacement of the "original" genetic background with that of the Canton Special wild-type strain. The mushroom body miniature gene (mbm) was investigated in detail. mbm supports the maintenance of MB Kenyon cell fibers in third instar larvae and their regrowth during metamorphosis. Adult mbm1 mutant females are lacking many or most Kenyon cell fibers and are impaired in MB-mediated associative odor learning. We show here that structural defects in mbm1 are apparent only in combination with an X-linked, dosage-dependent modifier (or modifiers). In the Canton Special genetic background, the mbm1 anatomical phenotype is suppressed, and MBs develop to a normal size. However, the olfactory learning phenotype is not fully restored, suggesting that submicroscopic defects persist in the MBs. Mutant mbm1 flies with full-sized MBs have normal retention but show a specific acquisition deficit that cannot be attributed to reductions in odor avoidance, shock reactivity, or locomotor behavior. We propose that polymorphic gene interactions (in addition to ontogenetic factors) determine MB size and, concomitantly, the ability to recognize and learn odors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.