ArticleProceedings of the National Academy of Sciences of the United States of America1996
Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 57 citations in OpenAlex.
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- Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling.Nucleic acids research · 2006Review
- Plasticity of the GABAergic phenotype of the "glutamatergic" granule cells of the rat dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Molecular correlates of the M-current in cultured rat hippocampal neurons.The Journal of physiology · 2002Article
- Does the Development of a GABAergic Phenotype by Hippocampal Dentate Gyrus Granule Cells Contribute to Epileptogenesis.Epilepsy currents · 2002Article
- Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Presence and phosphorylation of transcription factors in developing dendrites.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neurons in very low density hippocampal cultures that are physiologically identified as either GABAergic inhibitory or glutamatergic excitatory all contain mRNA for the gamma-aminobutyric acid (GABA) synthetic enzyme, glutamic acid decarboxylase (GAD), as detected by single cell mRNA amplification and PCR. However, consistent with the physiology, immunocytochemistry revealed that only a subset of the neurons stain for either GAD protein or GABA. A similar fraction hybridize with RNA probes for GAD65 and GAD67. Hippocampal CA1 pyramidal neurons in slice preparations, which are traditionally thought to be excitatory, also contain mRNA for GAD65 and GAD67. Hippocampal neurons in culture did not contain mRNA for two other neurotransmitter synthesizing enzymes, tyrosine hydroxylase, and choline acetyl transferase. These data suggest that in some neurons, presumably the excitatory neurons, GAD mRNA is selectively regulated at the level of translation. We propose that neurotransmitter phenotype may be posttranscriptionally regulated and neurons may exhibit transient phenotypic plasticity in response to environmental influences.
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