ArticleProceedings of the National Academy of Sciences of the United States of America1996
Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 74 citations in OpenAlex.
- Prevention of graft-versus-host-disease with preserved graft-versus-leukemia-effect by ex vivo and in vivo modulation of CD4(+) T-cells.Cellular and molecular life sciences : CMLS · 2014Article
- Modulation of innate antigen-presenting cell function by pre-patent schistosome infection.PLoS neglected tropical diseases · 2013Article
- Alkylating HIV-1 Nef - a potential way of HIV intervention.AIDS research and therapy · 2010Article
- Article
- Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.Journal of cellular and molecular medicine · 2008Review
- IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling.European journal of immunology · 2005Article
- Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand.The Journal of experimental medicine · 2002Article
- Article
- Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract.Nature medicine · 2002Article
- Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation.Journal of virology · 2001Article
- T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide.Journal of virology · 2000Article
- T-cell anergy induced by clonotype-specific antibodies: modulation of an autoreactive human T-cell clone in vitro.Immunology · 1999Article
- Role of interleukin-2 in superantigen-induced T-cell anergy.Immunology · 1999Article
- Altered peptide ligands act as partial agonists by inhibiting phospholipase C activity induced by myasthenogenic T cell epitopes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Individual T cells hold unexpected clues to the nature of anergy and memory.Immunologic research · 1998Review
- Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells.The Journal of experimental medicine · 1997Article
- Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors.The Journal of experimental medicine · 1997Article
- The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Full activation of T cells requires signaling through the T-cell antigen receptor (TCR) and additional surface molecules interacting with ligands on the antigen-presenting cell. TCR recognition of agonist ligands in the absence of accessory signals frequently results in the induction of a state of unresponsiveness termed anergy. However, even in the presence of costimulation, anergy can be induced by TCR partial agonists. The unique pattern of early receptor-induced tyrosine phosphorylation events induced by partial agonists has led to the hypothesis that altered TCR signaling is directly responsible for the development of anergy. Here we show that anergy induction is neither correlated with nor irreversibly determined by the pattern of early TCR-induced phosphorylation. Rather, it appears to result from the absence of downstream events related to interleukin 2 receptor occupancy and/or cell division. This implies that the anergic state can be manipulated independently of the precise pattern of early biochemical changes following TCR occupancy, a finding with implications for understanding the induction of self-tolerance and the use of partial agonist ligands in the treatment of autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.