ArticleProceedings of the National Academy of Sciences of the United States of America1996
Functional specificity of Hoxa-4 in vertebral patterning lies outside of the homeodomain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Identification of heterogeneous subtypes and a prognostic model for gliomas based on mitochondrial dysfunction and oxidative stress-related genes.Frontiers in immunology · 2023Article
- Hox transcription factors influence motoneuron identity through the integrated actions of both homeodomain and non-homeodomain regions.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Evolution of invertebrate deuterostomes and Hox/ParaHox genes.Genomics, proteomics & bioinformatics · 2011Review
- Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Birth defects research. Part B, Developmental and reproductive toxicology · 2007Review
- Distinct hox protein sequences determine specificity in different tissues.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.Molecular and cellular biology · 1998Article
- Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The Hox family of proteins plays a central role in establishing the body plan of a wide range of metazoan organisms. Each member of this family of transcriptional regulators has a distinct functional specificity, yet they bind to similar DNA target sequences through their conserved homeodomain. The mechanisms whereby Hox proteins achieve their diverse specificities in vivo remain undefined. Using the opposing effects of Hoxa-4 and Hoxc-8 in vertebral patterning, we demonstrate by replacing the homeodomain of Hoxa-4 with that of Hoxc-8 that the functional specificity of Hoxa-4 does not track with the homeodomain. These observations provide evidence that other regions of Hox proteins play an important role in mediating functional specificity during mammalian embryogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.