ArticleProceedings of the National Academy of Sciences of the United States of America1996
Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 308 citations in OpenAlex.
- Effects of docosahexaenoic supplementation and in vitro vitamin C on the oxidative and inflammatory neutrophil response to activation.Oxidative medicine and cellular longevity · 2015Trial
- Trial
- Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model.International journal of environmental research and public health · 2022Article
- A Novel Approach to Vaccine Development: Concomitant Pathogen Inactivation and Host Immune Stimulation by Peroxynitrite.Vaccines · 2022Article
- Extracellular DNA Traps: Origin, Function and Implications for Anti-Cancer Therapies.Frontiers in oncology · 2022Review
- Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury.Journal of neuroinflammation · 2021Article
- Evolution of the Knowledge of Free Radicals and Other Oxidants.Oxidative medicine and cellular longevity · 2020Review
- Reactive species and pathogen antioxidant networks during phagocytosis.The Journal of experimental medicine · 2019Review
- Differential effects of Th17 cytokines during the response of neutrophils toCentral-European journal of immunology · 2019Article
- The role of neutrophils in host defense against invasive fungal infections.Current clinical microbiology reports · 2018Article
- Silver oxide nanoparticles alleviate indomethacin-induced gastric injury: a novel antiulcer agent.Inflammopharmacology · 2018Article
- Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine.Proceedings of the National Academy of Sciences of the United States of America · 2018Review
- CCancer nanotechnology · 2018Article
- Tyrosine-Nitrated Proteins: Proteomic and Bioanalytical Aspects.Antioxidants & redox signaling · 2017Review
- Ultrastructural, ssrDNA sequencing of Myxobolus prochilodus and Myxobolus porofilus and details of the interaction with the host Prochilodus lineatus.Parasitology research · 2016Article
- Neutrophil-generated oxidative stress and protein damage in Staphylococcus aureus.Pathogens and disease · 2016Review
- Sequential Immune Responses: The Weapons of Immunity.Journal of innate immunity · 2015Review
- Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection.BioMed research international · 2015Article
- Nitric oxide production by polymorphonuclear leucocytes in infected cystic fibrosis sputum consumes oxygen.Clinical and experimental immunology · 2014Article
- The multifaceted functions of neutrophils.Annual review of pathology · 2014Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the production of NO within rodent phagocytes is well-characterized, its production and function within human phagocytes are less clear. We show here that neutrophils within human buffy coat preparations stimulated with a mixture of interleukin 1, tumor necrosis factor alpha, and interferon gamma contain inducible NO synthase mRNA and protein, one of the enzymes responsible for NO production. The protein colocalizes with myeloperoxidase within neutrophil primary granules. Using an inhibitor of NO synthase, L-N-monomethyl arginine, we show that activity of this enzyme is required for the formation of nitrotyrosine around phagocytosed bacteria, most likely through the intermediate production of peroxynitrite, a reaction product of NO and superoxide anions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.