ArticleProceedings of the National Academy of Sciences of the United States of America1996
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 134 citations in OpenAlex.
- Mechanistic basis for the antifibrotic actions of cAMP-based therapies.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Effect of Dipyridamole on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Pathogenicity.Investigative ophthalmology & visual science · 2025Article
- Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges.Frontiers in immunology · 2023Review
- Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer.Signal transduction and targeted therapy · 2021Review
- Antagonism of STAT3 signalling by Ebola virus.PLoS pathogens · 2021Article
- Macrophages as Emerging Key Players in Mitochondrial Transfers.Frontiers in cell and developmental biology · 2021Review
- Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways.Journal of experimental & clinical cancer research : CR · 2020Review
- Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Effects of thyroid-stimulating hormone on adhesion molecules and pro-inflammatory cytokines secretion in human umbilical vein endothelial cells.Research in pharmaceutical sciences · 2018Article
- Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis.Frontiers in endocrinology · 2018Review
- STAT3 activation in endothelial cells is important for tumor metastasis via increased cell adhesion molecule expression.Oncogene · 2017Article
- Galectin-1 promotes an M2 macrophage response to polydioxanone scaffolds.Journal of biomedical materials research. Part A · 2017Article
- Redox Imbalance in the Development of Colorectal Cancer.Journal of Cancer · 2017Review
- Atractylodin Inhibits Interleukin-6 by Blocking NPM-ALK Activation and MAPKs in HMC-1.Molecules (Basel, Switzerland) · 2016Article
- Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response.PLoS pathogens · 2016Article
- Natural Agents Used in Chemoprevention of Aerodigestive and GI Cancers.Current pharmacology reports · 2016Article
- Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts.Nature communications · 2015Article
- Cytokines: Names and Numbers You Should Care About.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients.Diabetologia · 2010Article
- Cytokines and glucocorticoid receptor signaling. Relevance to major depression.Annals of the New York Academy of Sciences · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important component of cytokine regulation of cell growth and differentiation is rapid transcriptional activation of genes by the JAK-STAT (signal transducer and activator of transcription) signaling pathway. Ligation of cytokine receptors results in tyrosine phosphorylation and activation of receptor-associated Jak protein tyrosine kinases and cytoplasmic STAT transcription factors, which then translocate to the nucleus. We describe the interruption of cytokine triggered JAK-STAT signals by cAMP, the calcium ionophore ionomycin, and granulocyte/macrophage colony-stimulating factor. Jak1 kinase activity, interleukin 6-induced gene activation, Stat3 tyrosine phosphorylation, and DNA-binding were inhibited, as was activation of Jak1 and Stat1 by interferon gamma. The kinetics and requirement for new RNA and protein synthesis for inhibition of interleukin 6 by ionomycin and GM-CSF differed, but both agents increased the association of Jak1 with protein tyrosine phosphatase ID (SH2-containing phosphatase 2). Our results demonstrate that crosstalk with distinct signaling pathways can inhibit JAK-STAT signal transduction, and suggest approaches for modulating cytokine activity during immune responses and inflammatory processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.