ReviewProceedings of the National Academy of Sciences of the United States of America1996
DNA sequence insertion and evolutionary variation in gene regulation.
Review in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 253 citations in OpenAlex.
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- Identification and functional characterization of the German cockroach, Blattella germanica, short interspersed nuclear elements.PloS one · 2022Article
- A review of computational algorithms for CpG islands detection.Journal of biosciences · 2019Review
- TEtools facilitates big data expression analysis of transposable elements and reveals an antagonism between their activity and that of piRNA genes.Nucleic acids research · 2017Article
- Exploratory bioinformatics investigation reveals importance of "junk" DNA in early embryo development.BMC genomics · 2017Article
- Molecular Evolution of piggyBac Superfamily: From Selfishness to Domestication.Genome biology and evolution · 2017Article
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- Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells.Skeletal muscle · 2015Article
- A Deluge of Complex Repeats: The Solanum Genome.PloS one · 2015Article
- The emerging roles of eRNAs in transcriptional regulatory networks.RNA biology · 2014Article
- Losing identity: structural diversity of transposable elements belonging to different classes in the genome of Anopheles gambiae.BMC genomics · 2012Article
- A fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish.PloS one · 2012Article
- Adaptive microclimatic evolution of the dehydrin 6 gene in wild barley at "Evolution Canyon", Israel.Genetica · 2011Article
- Nuclear receptor HNF4α binding sequences are widespread in Alu repeats.BMC genomics · 2011Article
- Formation of regulatory modules by local sequence duplication.PLoS computational biology · 2011Article
- Article
- Origin and evolution of a placental-specific microRNA family in the human genome.BMC evolutionary biology · 2010Article
- A c-Myc regulatory subnetwork from human transposable element sequences.Molecular bioSystems · 2009Article
- Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.BMC genomics · 2009Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current evidence on the long-term evolutionary effect of insertion of sequence elements into gene regions is reviewed, restricted to cases where a sequence derived from a past insertion participates in the regulation of expression of a useful gene. Ten such examples in eukaryotes demonstrate that segments of repetitive DNA or mobile elements have been inserted in the past in gene regions, have been preserved, sometimes modified by selection, and now affect control of transcription of the adjacent gene. Included are only examples in which transcription control was modified by the insert. Several cases in which merely transcription initiation occurred in the insert were set aside. Two of the examples involved the long terminal repeats of mammalian endogenous retroviruses. Another two examples were control of transcription by repeated sequence inserts in sea urchin genomes. There are now six published examples in which Alu sequences were inserted long ago into human gene regions, were modified, and now are central in control/enhancement of transcription. The number of published examples of Alu sequences affecting gene control has grown threefold in the last year and is likely to continue growing. Taken together, all of these examples show that the insertion of sequence elements in the genome has been a significant source of regulatory variation in evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.