ReviewProceedings of the National Academy of Sciences of the United States of America1996
Modular cis-regulatory organization of developmentally expressed genes: two genes transcribed territorially in the sea urchin embryo, and additional examples.
Review in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 104 citations in OpenAlex.
- How Does the Regulatory Genome Work?Journal of computational biology : a journal of computational molecular cell biology · 2019Article
- Review
- Highly conserved elements discovered in vertebrates are present in non-syntenic loci of tunicates, act as enhancers and can be transcribed during development.Nucleic acids research · 2013Article
- Article
- Multidimensional adaptive evolution of a feed-forward network and the illusion of compensation.Evolution; international journal of organic evolution · 2013Article
- Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding.Genome research · 2012Article
- Conserved Motifs and Prediction of Regulatory Modules in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
- Article
- Transcriptional enhancers in animal development and evolution.Current biology : CB · 2010Article
- Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila.Development (Cambridge, England) · 2010Review
- Scoring overlapping and adjacent signals from genome-wide ChIP and DamID assays.Molecular bioSystems · 2009Review
- Genomic control of patterning.The International journal of developmental biology · 2009Review
- Transcriptional regulation of NADP-dependent malate dehydrogenase: comparative genetics and identification of DNA-binding proteins.Journal of molecular evolution · 2007Article
- Comparative analysis of regulatory motif discovery tools for transcription factor binding sites.Genomics, proteomics & bioinformatics · 2007Article
- Identification of muscle-specific regulatory modules in Caenorhabditis elegans.Genome research · 2007Article
- PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation.Genome biology · 2007Article
- An evolutionary constraint: strongly disfavored class of change in DNA sequence during divergence of cis-regulatory modules.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Logic functions of the genomic cis-regulatory code.Proceedings of the National Academy of Sciences of the United States of America · 2005Review
- Molecular evolution of the HoxA cluster in the three major gnathostome lineages.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
The cis-regulatory systems that control developmental expression of two sea urchin genes have been subjected to detailed functional analysis. Both systems are modular in organization: specific, separable fragments of the cis-regulatory DNA each containing multiple transcription factor target sites execute particular regulatory subfunctions when associated with reporter genes and introduced into the embryo. The studies summarized here were carried out on the CyIIIa gene, expressed in the embryonic aboral ectoderm and on the Endo16 gene, expressed in the embryonic vegetal plate, archenteron, and then midgut. The regulatory systems of both genes include modules that control particular aspects of temporal and spatial expression, and in both the territorial boundaries of expression depend on a combination of negative and positive functions. In both genes different regulatory modules control early and late embryonic expression. Modular cis-regulatory organization is widespread in developmentally regulated genes, and we present a tabular summary that includes many examples from mouse and Drosophila. We regard cis-regulatory modules as units of developmental transcription control, and also of evolution, in the assembly of transcription control systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.