ArticleBritish journal of pharmacology1996
Increase in insulin release from rat pancreatic islets by quinolone antibiotics.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 99 citations in OpenAlex.
- A randomized, double-blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women.Diabetes, obesity & metabolism · 2023Trial
- Fluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Drug Utilization Evaluation Study of Ciprofloxacin Use and Adverse Events Occurrence: Role of Community Pharmacists.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024Article
- Hypoglycemia and anxiolysis mediated by levofloxacin treatment in diabetic rats.Journal of diabetes and metabolic disorders · 2023Article
- Risk of non-hypoglycemic agents for hypoglycemia-related hospitalization in patients with type 2 diabetes: a large-scale medical receipt database analysis.BMJ open diabetes research & care · 2023Article
- Risk for hypoglycemic emergency with levofloxacin use, a population-based propensity score matched nested case-control study.PloS one · 2022Article
- Fatal hypoglycemia with ciprofloxacin in a dialysis patient: A case report.Clinical case reports · 2021Article
- Recurrent Hypoglycemia in a Case of Congenital Analbuminemia.Case reports in endocrinology · 2020Article
- Ciprofloxacin and risk of hypolycemia in non-diabetic patients.Journal of medical case reports · 2019Article
- Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review.Case reports in critical care · 2019Article
- Clinically and pharmacologically relevant interactions of antidiabetic drugs.Therapeutic advances in endocrinology and metabolism · 2016Review
- Evaluation of the appropriate use of commonly prescribed fluoroquinolones and the risk of dysglycemia.Therapeutics and clinical risk management · 2015Article
- Hypoglycemia after antimicrobial drug prescription for older patients using sulfonylureas.JAMA internal medicine · 2014Article
- Hypoglycemia revisited in the acute care setting.Yonsei medical journal · 2011Article
- Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes.Drug safety · 2009Review
- Dysglycaemias and fluoroquinolones.Drug safety · 2008Review
- An overview of harms associated with beta-lactam antimicrobials: where do the carbapenems fit in?Critical care (London, England) · 2008Review
- Recurrent episodes of hypoglycemia induced by moxifloxacin.Indian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The present study was undertaken to elucidate the mechanism(s) of hypoglycaemia caused by quinolone antibiotics. We investigated the effects of various quinolone antibiotics on insulin release in rat pancreatic islets. 2. At a non-stimulatory concentration of 3 mM glucose, lomefloxacin (LFLX) or sparfloxacin at 1 mM and pipemidic acid (0.1-1 mM) induced slight insulin release but tosufloxacin or enoxacin up to 100 microM did not. 3. At the stimulatory concentration of 10 mM glucose, all quinolones augmented insulin release in a dose-dependent manner. LFLX (100 microM) shifted the dose-response curve of glucose-induced insulin release to the left without altering the maximal response. 4. At 10 mM glucose, LFLX (100 microM) increased insulin release augmented by forskolin (5 microM) or 12-O-tetradecanoyl phorbol-13-acetate (100 nM) but not by raising the K+ concentration from 6 to 25 mM. 5. Verapamil (50 microM) or diazoxide (50-400 microM) antagonized the insulinotropic effect of LFLX. 6. These data suggest that quinolone antibiotics may cause hypoglycaemia by increasing insulin release via blockade of ATP-sensitive K+ channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.