ArticleThe Journal of physiology1995
Nitric oxide activates multiple potassium channels in canine colonic smooth muscle.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 166 citations in OpenAlex.
- Trial
- Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model.Journal of neural engineering · 2024Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel-Part 1: Modulation of TRPM4.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Mechanisms Associated to Nitroxyl (HNO)-Induced Relaxation in the Intestinal Smooth Muscle.Frontiers in physiology · 2020Article
- Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract.British journal of pharmacology · 2019Review
- Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter.Alcohol (Fayetteville, N.Y.) · 2018Article
- Thioredoxin shapes theeLife · 2018Article
- Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers.Antioxidants & redox signaling · 2017Review
- Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present.Pflugers Archiv : European journal of physiology · 2015Review
- The significance of interstitial cells in neurogastroenterology.Journal of neurogastroenterology and motility · 2014Article
- Regulation of gastrointestinal motility--insights from smooth muscle biology.Nature reviews. Gastroenterology & hepatology · 2012Review
- CaMKII inhibition hyperpolarizes membrane and blocks nitrergic IJP by closing a Cl(-) conductance in intestinal smooth muscle.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Neuroeffector apparatus in gastrointestinal smooth muscle organs.The Journal of physiology · 2010Review
- Interstitial cells of Cajal contain signalling molecules for transduction of nitrergic stimulation in guinea pig caecum.Neurogastroenterology and motility · 2009Article
- Regulation of basal tone, relaxation and contraction of the lower oesophageal sphincter. Relevance to drug discovery for oesophageal disorders.British journal of pharmacology · 2008Review
- Block of inhibitory junction potentials and TREK-1 channels in murine colon by Ca2+ store-active drugs.The Journal of physiology · 2008Article
- Inhibition of pacemaker currents by nitric oxide via activation of ATP-sensitive K+ channels in cultured interstitial cells of Cajal from the mouse small intestine.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
- Exercise training increases basal tone in arterioles distal to chronic coronary occlusion.American journal of physiology. Heart and circulatory physiology · 2006Article
- Two-pore-domain potassium channels in smooth muscles: new components of myogenic regulation.The Journal of physiology · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1. Nitric oxide (NO), an inhibitory neurotransmitter released from peripheral neurones, hyperpolarizes smooth muscle cells and inhibits contraction. The mechanism of this hyperpolarization is unknown. 2. We have identified three classes of K+ channels activated by NO and NO donors in colonic smooth muscle cells. NO and NO donors increased the open probability of 80 pS channels (KNO1), very small channels (< 4 pS, KNO2), and 270 pS Ca(2+)-activated K+ channels (BK channels) in cell-attached patches. 3. Dibutyryl cGMP and 8-bromo cGMP also increased the open probability of KNO1 and KNO2 in cell-attached patches. 4. In excised patches of membrane, direct application of NO or the NO donor, S-nitroso-N-acetyl penicillamine (SNAP), increased the open probability of KNO1 and KNO2, but cGMP or dibutyryl cGMP had no effect. SNAP had no effect on the open probability of BK channels in excised patches. 5. The reducing agent dithiothreitol and the alkylating agent N-ethylmaleimide blocked NO-induced channel openings. 6. In summary, the hyperpolarization response to NO in smooth muscles may be mediated by multiple K+ channels. At least two of these classes of channels may be activated by dual pathways involving direct activation by NO and cGMP-mediated mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.