ArticleThe Journal of physiology1995
Calcium-induced calcium release in rat sensory neurons.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 117 citations in OpenAlex.
- Voltage-gated calcium channels as key regulators of neuronal differentiation in the immortalized dorsal root ganglion neuronal cell line F11.Scientific reports · 2026Article
- Visual input drives diverse ER calcium signals in neuronsbioRxiv : the preprint server for biology · 2025Article
- A CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A biophysically detailed computational model of urinary bladder small DRG neuron soma.PLoS computational biology · 2018Article
- Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons.Neuropharmacology · 2017Article
- Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IPThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Ca2+ removal by the plasma membrane Ca2+-ATPase influences the contribution of mitochondria to activity-dependent Ca2+ dynamics in Aplysia neuroendocrine cells.Journal of neurophysiology · 2016Article
- Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients.Cell calcium · 2016Review
- The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.PloS one · 2015Article
- Role of intracellular calcium stores in hair-cell ribbon synapse.Frontiers in cellular neuroscience · 2014Review
- Regulation of dendritic calcium release in striatal spiny projection neurons.Journal of neurophysiology · 2013Article
- Article
- Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons.Journal of hypertension · 2008Article
- Roles of mitochondria and temperature in the control of intracellular calcium in adult rat sensory neurons.Cell calcium · 2008Article
- Epinephrine enhances the sensitivity of rat vagal chemosensitive neurons: role of beta3-adrenoceptor.Journal of applied physiology (Bethesda, Md. : 1985) · 2007Article
- Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons.The Journal of physiology · 2006Article
- CaMKII inactivation by extracellular Ca(2+) depletion in dorsal root ganglion neurons.Cell calcium · 2006Article
- Ca2+ sparks and secretion in dorsal root ganglion neurons.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In isolated dorsal root ganglion cells (DRG neurons), changes in the concentration of global cytosolic Ca2+ (delta [Ca2+]c) were measured by the fluorescence of K5-indo-1. Depolarizations from -60 to 0 mV (500 ms) and Ca2+ influx through Ca2+ channels (ICa) increased [Ca2+]c by 480 +/- 113 nM, the peak occurring 542 +/- 76 ms (mean +/- S.E.M.) after repolarization. 2. Ryanodine (10 microM) reduced depolarization-induced delta [Ca2+]c by up to 80% and blocked delta [Ca2+]c induced by 20 mM caffeine. 3. Peak delta [Ca2+]c and peak ICa followed a similar bell-shaped voltage dependence. Removal of extracellular Ca2+ abolished depolarization-induced delta [Ca2+]c; its elevation from 2 to 8 mM increased peak ICa by 30% and delta [Ca2+]c by 108%. 4. Ca2+ influx at 0 mV was graded by pulse durations between 20 and 500 ms. Up to 200 ms, delta [Ca2+]c increased linearly with Ca2+ influx. Depolarizations longer than 200 ms induced a supralinear increase in delta [Ca2+]c that was abolished by caffeine (20 mM). 5. The supralinear increase in delta [Ca2+]c and the caffeine-induced delta [Ca2+]c were measured only in thirteen of nineteen DRG neurons; in the other six of nineteen cells both properties were absent. The results suggest that Ca(2+)-induced Ca2+ release (CICR) is expressed differently in different populations of DRG neurons. 6. A single action potential did not significantly increase [Ca2+]c. Trains of stimuli (20 Hz) induced delta [Ca2+]c that linearly increased with the number of action potentials. Delta [Ca2+]c due to 100 action potentials had a significant ryanodine-sensitive component. 7. It is discussed that CICR can contribute to the depolarization-induced [Ca2+]c, provided the Ca2+ influx lasts for a certain minimum period of time.
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