ArticleActa neuropathologica1996
Differences in origin and fate between the cranial and caudal spinal cord during normal and disturbed human development.
Article in Acta neuropathologica, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 23 citations in OpenAlex.
- Junctional Neural Tube Defect (JNTD): A Rare and Relatively New Spinal Dysraphic Malformation.Advances and technical standards in neurosurgery · 2023Article
- From Bipotent Neuromesodermal Progenitors to Neural-Mesodermal Interactions during Embryonic Development.International journal of molecular sciences · 2021Review
- Expression Pattern of 5-HT (Serotonin) Receptors during Normal Development of the Human Spinal Cord and Ganglia and in Fetus with Cervical Spina Bifida.International journal of molecular sciences · 2021Article
- Junctional Neural Tube Defect.Journal of Korean Neurosurgical Society · 2020Article
- Unjoined primary and secondary neural tubes: junctional neural tube defect, a new form of spinal dysraphism caused by disturbance of junctional neurulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Junctional neural tube defect in a newborn: report of a fourth case.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Interplay of proliferation and differentiation factors is revealed in the early human eye development.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Differences in histological appearance between the cranial and caudal parts of the spinal cord and associated axial organs were analyzed in 9- and 15-week-old human dysraphic fetuses and compared with normal fetuses. In human development the cranial part of the neural tube down to the lumbosacral level forms during primary neurulation, while its caudal part results from secondary neurulation. In the 9-week fetus with cervical spina bifida, the cranial spinal cord displayed a variety of morphological changes along the cranio-caudal axis. Spinal cord in the upper cervical region transformed into the area cerebrovasculosa, while the lower cervical and thoracic levels showed only disturbed differentiation of the cell layers and roof plate. The degree of the cranial spinal cord dysmorphogenesis correlated with anomalies of the underlying notochord and vertebral column. The caudal to lumbosacral region of the spinal cord appeared normal. In the case of the 15-week-old fetus with complete dysraphia, the area cerebrovasculosa was found along the whole extent of the cranial spinal cord, while more caudally, all axial organs showed a normal histological structure. Our findings confirmed a different origin for the cranial and caudal parts of the human spinal cord. The appearance of dysraphic disorders corresponded to the time of primary neurulation; therefore, they resulted in the faulty formation of the cranial spinal cord. Normally formed caudal spinal cord appears during secondary neurulation at later developmental stages.
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