ArticlePharmaceutical research1995
Regional drug delivery I: permeability characteristics of the rat 6-day-old air pouch model of inflammation.
Article in Pharmaceutical research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Expression of arachidonic acid-metabolizing cytochrome P450s in human megakaryocytic Dami cells.In vitro cellular & developmental biology. Animal · 2013Article
- Intradermal air pouch leukocytosis as an in vivo test for nanoparticles.International journal of nanomedicine · 2013Article
- Drug structure-transport relationships.Journal of pharmacokinetics and pharmacodynamics · 2010Review
- Pharmacokinetics of nonsteroidal anti-inflammatory drugs in synovial fluid.Clinical pharmacokinetics · 1999Review
- Pharmacokinetic considerations of regional administration and drug targeting: influence of site of input in target tissue and flux of binding protein.Journal of pharmacokinetics and biopharmaceutics · 1996Article
- Regional drug delivery II: relationship between drug targeting index and pharmacokinetic parameters for three non-steroidal anti-inflammatory drugs using the rat air pouch model of inflammation.Pharmaceutical research · 1995Article
- Discrepancies in pharmacokinetic parameter estimation between bolus and infusion studies in the perfused rat hindlimb.Journal of pharmacokinetics and biopharmaceutics · 1995Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the permeability characteristics of the rat air pouch model of inflammation using permeability extremes within which the NSAIDs S[+] ibuprofen, piroxicam and diclofenac could be evaluated.
methodsPermeability was calculated using concentration data obtained following intrapouch and intravenous administration of [3H]-water, [14C]-urea, [14C]-inulin and [125I]-albumin and compared to similar data obtained for the three NSAIDs.
resultsSimilar permeability values (5-6.5 ml hr-1) were obtained for the three NSAIDS which fell between the permeability extremes of the molecular weight markers [3H]-water (9.7 ml hr-1), [14C]-urea (6.8 ml hr-1), [14C]-inulin (1.0 ml hr-1) and [125I]-albumin (0.6 ml hr-1). Coadministration of equipotent anti-inflammatory doses of the NSAIDs did not affect local blood flow to the air pouch (as assessed by urea kinetics) but did reduced vascular permeability (as assessed by albumin flux into the pouch).
conclusionsComparison of the NSAIDs with the permeabilities of the molecular weight markers indicates that a perfusion rate limitation probably exists. Systemic absorption is complete over the first two hours following intrapouch administration of the NSAIDs, therefore albumin flux into the pouch is insufficient to materially affect the permeability of the NSAIDs. However, subsequently (post 5hr) albumin concentration in the pouch rises sufficiently to lower the effective flux of the NSAIDs.
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