ArticleHuman genetics1996
Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors.
Article in Human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 56 citations in OpenAlex.
- New prognostic scales LAST-1 and LAST-2: supporting prediction and staging of thyroid cancer.World journal of surgery · 2006Article
- A newly identified RET proto-oncogene polymorphism is found in a high number of endocrine tumor patients.Human genetics · 2005Article
- Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.Cell stress & chaperones · 2005Article
- Chromosomal imbalances associated with anaplastic transformation of follicular thyroid carcinomas.British journal of cancer · 2004Article
- Article
- Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors.The American journal of pathology · 2000Article
- PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.Japanese journal of cancer research : Gann · 2000Article
- Evaluation of Endocrine Neoplasms Using Fine Needle Aspiration Biopsy.Endocrine pathology · 2000Article
- Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.British journal of cancer · 1999Article
- Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis.American journal of human genetics · 1997Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies of follicular thyroid tumors have shown loss of heterozygosity (LOH) on the short arm of chromosome 3 in carcinomas, and on chromosome 10 in atypical adenomas and carcinomas, but not in common adenomas. We studied LOH on these chromosomal arms in 15 follicular thyroid carcinomas, 19 atypical follicular adenomas and 6 anaplastic (undifferentiated) carcinomas. Deletion mapping of chromosome 10 using 15 polymorphic markers showed that 15 (37.5%) of the tumors displayed LOH somewhere along the long arm. Thirteen of these tumors showed deletions involving the telomeric part of chromosome 10q, distal to D10S187. LOH on chromosome 3p was found in 8 (20%) cases. Seven of these also showed LOH on chromosome 10q. In eight cases LOH was seen on chromosome 10q but not 3p. In comparison, the retinoblastoma gene locus at chromosome 13q showed LOH in 22% of the tumors. Most of these also had deletions on chromosome 10q. The results indicate that a region at the telomeric part of 1Oq may be involved in progression of follicular thyroid tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.