ArticleDiabetologia1995
Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Traditional chinese medicine to prevent and treat diabetic erectile dysfunction.Frontiers in pharmacology · 2022Review
- Tocomin Restores Endothelium-Dependent Relaxation in the Diabetic Rat Aorta by Increasing NO Bioavailability and Improving the Expression of eNOS.Frontiers in physiology · 2019Article
- Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes.Journal of cardiovascular pharmacology · 2015Review
- The effects of combined free radical scavenger and sildenafil therapy on age-associated erectile dysfunction: An animal model.Urology annals · 2014Article
- Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.The open cardiovascular medicine journal · 2010Article
- Cardiovascular determinants of life span.Pflugers Archiv : European journal of physiology · 2010Review
- Therapeutic interventions and oxidative stress in diabetes.Frontiers in bioscience (Landmark edition) · 2009Review
- Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function.Diabetologia · 2008Article
- Endothelium-dependent contractions in hypertension.British journal of pharmacology · 2005Review
- Article
- Effect of PDE5 inhibition combined with free oxygen radical scavenger therapy on erectile function in a diabetic animal model.International journal of impotence research · 2003Article
- Endothelial dysfunction in diabetes.British journal of pharmacology · 2000Review
- Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes.The Journal of clinical investigation · 1997Article
- Changes in superoxide dismutase mRNA expression by streptozotocin-induced diabetes.British journal of pharmacology · 1996Article
- Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats.Diabetologia · 1996Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We examined the effect in rats of 2 months of streptozotocin-induced diabetes mellitus on relaxation and contraction of aortas in vitro. A further diabetic group was treated from time of diabetes induction with a 1% dietary supplement of vitamin E. Diabetes caused a 26.5% deficit (p < 0.001) in maximum endothelium-dependent relaxation to acetylcholine in phenylephrine-precontracted aortas. This was 64.3% attenuated (p < 0.01) by vitamin E treatment; maximum relaxation was not significantly altered compared to non-diabetic rats. Vitamin E treatment of non-diabetic rats did not significantly affect acetylcholine-induced relaxation. Diabetes or treatment did not significantly alter acetylcholine sensitivity. Endothelium-independent relaxation response to glyceryl trinitrate was not affected by diabetes or vitamin E treatment, indicating that vascular smooth muscle responses to nitric oxide remained unaltered. There was a 35.4% reduction in the maximum contractile response to phenylephrine with diabetes (p < 0.05) which was unaffected by vitamin E treatment. The data suggest that the chronic deficit in nitric oxide-mediated endothelium-dependent relaxation in diabetes depends largely upon excess activity of reactive oxygen species. Treatment with vitamin E to increase free radical scavenging specifically protected vascular endothelium although it had no effect on deficits in vascular smooth muscle contractile responses.
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