ReviewDiabetologia1995
Role of insulin resistance in the pathogenesis of NIDDM.
Review in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 118 citations in OpenAlex.
- Possible mechanisms of the hypoglycaemic effect of artesunate: Gender implication.Metabolism open · 2021Article
- Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation.Scientific reports · 2016Article
- Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice.Diabetologia · 2016Article
- The islet circadian clock: entrainment mechanisms, function and role in glucose homeostasis.Diabetes, obesity & metabolism · 2015Review
- Transcriptomic profiles of skeletal muscle tissue following an euglycemic-hyperinsulinemic clamp in insulin-resistant obese subjects.Genes & nutrition · 2013Article
- Pancreatic function, type 2 diabetes, and metabolism in aging.International journal of endocrinology · 2012Article
- Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction.Journal of biological rhythms · 2011Article
- Pancreatic β-Cell Mass as a Pharmacologic Target in Diabetes.McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students · 2009Article
- Article
- Targeting prandial hyperglycemia: how important is it and how best to do this?Current diabetes reports · 2008Article
- Regulation of GLUT4 gene expression by SREBP-1c in adipocytes.The Biochemical journal · 2006Article
- Management of type 2 diabetes mellitus and cardiovascular risk: lessons from intervention trials.Drugs · 2000Review
- Insulin resistance.BMJ (Clinical research ed.) · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The above discussion illustrating the multitude of variables which influence insulin sensitivity in normal subjects challenges the prevailing view that insulin sensitivity is genetically determined in patients with NIDDM. The lack of accurate quantitation of all determinants of insulin sensitivity in the cross-sectional studies, and the difficulty in distinguishing between insulin secretion and sensitivity in prospective studies implies that the inherited metabolic abnormality in NIDDM still remains to be defined. The methodological difficulties in assessing the fate of glucose in many insulin-resistant states raise the possibility that defects in glycogen synthesis may not be rate-limiting for insulin action. It seems more likely that defects in glucose transport or phosphorylation are rate-limiting for glucose disposal, and thus represent either the primary regulatory steps or the steps via which distal defects signal their influence on glucose uptake. The above considerations should not be interpreted to suggest that insulin resistance is unimportant in the pathogenesis of NIDDM. It clearly increases the risk of developing NIDDM, and more importantly, its early amelioration by lifestyle modification seems sufficient to prevent NIDDM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.