Evidence map›Paper›PMID 8785607›Full record

ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1996

The synaptonemal complex--the chaperone of crossing over.

C A Hasenkampf

Abstract read
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In one paragraph

Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

C A HasenkampfDivision of Life Science, University of Toronto-Scarborough Campus, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During meiosis homologous chromosomes pair and exchange homologous chromosome segments. The synaptonemal complex (SC) forms between paired chromosomes. The role of the SC in the process of reciprocal exchange of flanking markers is a matter of debate. I propose a dual pathway for reciprocal exchange of flanking markers (REFM). In the first, SC-independent, path, two 'half-nodules' and an independent REFM protein combine to form a functional recombination nodule (RN). The RN binds to paired chromosomes and accomplishes reciprocal exchange of flanking markers. In the other, SC-dependent, pathway 'half-nodules' occur at pairing initiation sites. 'Half-nodules' move along the SC as it forms. Assisted by an SC-bound REFM protein, 'half-nodules' combine to form functional RNs. I propose that different organisms rely to different extents on the two pathways, and hence rely to different extents on the SC.

Indexed as

AspergillusChromosomesCrossing Over, GeneticGenetic MarkersMeiosisModels, GeneticSaccharomycesSynaptonemal ComplexGenetic Markers

Identifiers

PMID8785607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.