ArticleBiophysical journal1996
A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Analysis of patchclamp recordings: model-free multiscale methods and software.European biophysics journal : EBJ · 2021Article
- Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels.Frontiers in neuroinformatics · 2017Article
- Statistical assessment of change point detectors for single molecule kinetic analysis.The Journal of membrane biology · 2013Article
- Test of normality for integrated change point detection and mixture modeling.The Journal of membrane biology · 2013Article
- Dynamics of the preprotein translocation channel of the outer membrane of mitochondria.Biophysical journal · 2008Article
- Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel.Pflugers Archiv : European journal of physiology · 2006Article
- K channel subconductance levels result from heteromeric pore conformations.The Journal of general physiology · 2005Article
- Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.The Journal of general physiology · 2004Article
- Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling.Biophysical journal · 2004Article
- C terminus L-type Ca2+ channel calmodulin-binding domains are 'auto-agonist' ligands in rabbit ventricular myocytes.The Journal of physiology · 2003Article
- Differential modulation of cardiac Ca2+ channel gating by beta-subunits.Biophysical journal · 2003Article
- Cytoskeletal disrupting agents prevent calmodulin kinase, IQ domain and voltage-dependent facilitation of L-type Ca2+ channels.The Journal of physiology · 2002Article
- Calmodulin kinase and a calmodulin-binding 'IQ' domain facilitate L-type Ca2+ current in rabbit ventricular myocytes by a common mechanism.The Journal of physiology · 2001Article
- Voltage-induced nonconductive pre-pores and metastable single pores in unmodified planar lipid bilayer.Biophysical journal · 2001Article
- GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity.The Journal of physiology · 2001Article
- Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Facilitation by the beta2a subunit of pore openings in cardiac Ca2+ channels.The Journal of physiology · 1998Article
- Redox modulation of hslo Ca2+-activated K+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Effect of alkali metal cations on slow inactivation of cardiac Na+ channels.The Journal of general physiology · 1997Article
- Role of transmembrane segment S5 on gating of voltage-dependent K+ channels.The Journal of general physiology · 1997Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
A new algorithm is presented for idealizing single channel data containing any number of conductance levels. The number of levels and their amplitudes do not have to be known a priori. No assumption has to be made about the behavior of the channel, other than that transitions between conductance levels are fast. The algorithm is relatively insensitive to the complexity of the underlying single channel behavior. Idealization may be reliable with signal-to-noise ratios as low as 3.5. The idealization algorithm uses a slope detector to localize transitions between levels and a relative amplitude criterion to remove spurious transitions. After estimating the number of conductances and their amplitudes, conductance states can be assigned to the idealized levels. In addition to improving the quality of the idealization, this "interpretation" allows a statistical analysis of individual (sub)conductance states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.