ArticleNeuron1996
TrkA activation is sufficient to rescue axotomized cholinergic neurons.
Article in Neuron, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Impact of Neuroimmune System Activation by Adolescent Binge Alcohol Exposure on Adult Neurobiology.Advances in experimental medicine and biology · 2025Review
- HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype.Molecular psychiatry · 2023Article
- Cholinergic REST-G9a gene repression through HMGB1-TLR4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype.Frontiers in molecular neuroscience · 2022Article
- Ablation of p75Translational psychiatry · 2021Article
- Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease.Science advances · 2020Article
- Activity-Dependent Inhibitory Synaptogenesis in Cerebellar Cultures.Brain plasticity (Amsterdam, Netherlands) · 2016Review
- Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases.International journal of molecular sciences · 2014Review
- The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Nerve growth factor regulates the firing patterns and synaptic composition of motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Nerve growth factor rapidly increases muscarinic tone in mouse medial septum/diagonal band of Broca.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Article
- Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Functional blockade of tyrosine kinase A in the rat basal forebrain by a novel antagonistic anti-receptor monoclonal antibody.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Signaling of neuronal cell death by the p75NTR neurotrophin receptor.Molecular neurobiology · 1999Review
- TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation.The European journal of neuroscience · 1999Article
- Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle.The Journal of clinical investigation · 1998Article
- Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
To test the molecular nature of the NGF receptor responsible for the ability of NGF to rescue septal cholinergic neurons following axotomy, we infused polyclonal antibodies that act as specific agonists of trkA (RTA) into the lateral ventricle of fimbria-fornix lesioned animals. Rats receiving chronic intraventricular infusions of RTA showed significantly more low affinity NGF receptor immunoreactive (p75NGFR-IR) neurons on the lesioned side than did control animals 2 weeks following unilateral fimbria-fornix lesion. RTA also initiated cholinergic sprouting. Infusions of RTA in combination with an antibody that blocks p75NGFR (REX) did not reduce the cell savings effect observed with RTA alone. However, animals infused with RTA plus REX demonstrated significantly less sprouting. These findings suggest that antibody-induced trkA activation is sufficient to mediate NGF-promoted survival of axotomized cholinergic neurons in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.