ArticleThe Journal of physiology1996
Active potassium transport across guinea-pig distal colon: action of secretagogues.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Proton-pump inhibitors increaseGut microbes · 2025Article
- Intact colonic KPhysiological reports · 2017Article
- Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- The impact of proton pump inhibitors on the human gastrointestinal microbiome.Clinics in laboratory medicine · 2014Review
- Omeprazole enhances the colonic expression of the Mg(2+) transporter TRPM6.Pflugers Archiv : European journal of physiology · 2013Article
- Extracellular nucleotides inhibit oxalate transport by human intestinal Caco-2-BBe cells through PKC-δ activation.American journal of physiology. Cell physiology · 2013Article
- Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Effects of proton pump inhibitor therapy in the distal gut: putting the pieces together.Digestive diseases and sciences · 2012Article
- Activation of the basolateral membrane Cl- conductance essential for electrogenic K+ secretion suppresses electrogenic Cl- secretion.Experimental physiology · 2011Article
- beta-Adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels.The Journal of physiology · 2010Article
- Colonic potassium handling.Pflugers Archiv : European journal of physiology · 2010Review
- Electrogenic Cl(-) secretion does not occur in the ileum of the Australian common brushtail possum, Trichosurus vulpecula, due to low levels of expression of the NaK2Cl cotransporter, NKCC1.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2009Article
- Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: desensitization via the Y2-neuropeptide receptor.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: involvement of beta1- and beta2-adrenergic receptors.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion.The Journal of physiology · 2008Article
- Effects of dopamine on ion transport across the rat distal colon.Pflugers Archiv : European journal of physiology · 2004Article
- Localization of cAMP- and aldosterone-induced K+ secretion in rat distal colon by conductance scanning.The Journal of physiology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. Adrenaline (5 microM) stimulated a K+ secretory current by 2.2 mu equiv h-1 cm-2 in isolated guinea-pig distal colonic epithelium. This secretory activity was inhibited entirely by addition of the loop diuretic bumetanide to the serosal solution. On-going K+ uptake via the absorptive pathway was unaltered by these changes. 2. Prostaglandin E2 (PGE2, 2 microM) stimulated electrogenic K+ secretion and Cl- secretion by 3.0 and 3.6 mu equiv h-1 cm-2, respectively. Serosal addition of bumetanide completely inhibited this K+ secretion but blocked only approximately 70% of Cl- secretion. The bumetanide-insensitive Cl- secretory current was dependent on the presence of Cl- and HCO3- in the bathing solutions. 3. Stimulation of electrogenic K+ secretion by PGE2 occurred with a half-maximal concentration of 4 nM, an affinity approximately 300 times higher than that for stimulation of Cl- secretion by PGE2. 4. Forskolin (10 microM) stimulated Cl- secretion by 4.9 mu equiv h-1 cm-2. The apparent K+ secretory rate was increased by only 1.5 mu equiv h-1 cm-2. A bumetanide-insensitive short-circuit current (ISC) was apparent and of the same size as that stimulated by PGE2. 5. Addition of the Ca2+ ionophore A23187 (10 microM), in the presence of indomethacin (1 microM) to reduce prostaglandin production, inhibited the K+ absorptive pathway by 40% and concurrently stimulated a small rate of electrogenic K+ secretion. 6. Active K+ absorption was inhibited by the addition of ouabain, omeprazole or SCH28080 to the mucosal solution. Both omeprazole and SCH28080 also stimulated a small negative ISC, consistent with electrogenic K+ secretion. 7. Association of K+ absorption, K+ secretion and Cl- secretion is indicated by similarities in transport mechanism and by secretagogue regulation. In particular, maximal rates of K+ secretory current require uptake via apical membrane K+ pumps. Such interrelations support a common cellular locus for these ion transport pathways.
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