ArticleEnvironmental health perspectives1996
The importance of age and smoking in evaluating adverse cytogenetic effects of exposure to environmental agents.
Article in Environmental health perspectives, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 42 citations in OpenAlex.
- Radiation effects of a CT scan on chromosomal aberrations in cancer and non-cancer patients.Journal of radiation research · 2026Article
- Cytogenetic abnormalities of the descendants of permanent residents of heavily contaminated East Kazakhstan.Radiation and environmental biophysics · 2017Article
- Chromosome aberrations in Japanese fishermen exposed to fallout radiation 420-1200 km distant from the nuclear explosion test site at Bikini Atoll: report 60 years after the incident.Radiation and environmental biophysics · 2016Article
- Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation.Journal of radiation research · 2015Article
- Chromosome analysis of nuclear power plant workers using fluorescence in situ hybridization and Giemsa assay.Journal of radiation research · 2013Article
- Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists.Cancer research · 2008Article
- Thyroid hormones and cytogenetic outcomes in backpack sprayers using ethylenebis(dithiocarbamate) (EBDC) fungicides in Mexico.Environmental health perspectives · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed people ranging in age from birth (cord bloods) to 79. We established a baseline frequency of stable aberrations that showed a highly significant curvilinear increase with age (p < 0.00001) that accounted for 70% of the variance among donors. The magnitude of this effect illustrates the importance of understanding the cytogenetic changes that occur with age, which is particularly important for quantifying the effects of prior adverse environmental, occupational, or accidental exposure. In this paper we use the data obtained in our previous study to characterize the distribution of stable aberrations by age and pack-years of cigarette smoking. We also provide estimates of the number of cell equivalents that need to be scored to detect a given increase in aberrations above the background level surveyed in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.