ArticlePflugers Archiv : European journal of physiology1996
Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 145 citations in OpenAlex.
- A Comparative Study of the Rapid (IPharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Marked oestrous cycle-dependent regulation of rat arterial KBritish journal of pharmacology · 2023Article
- Insights into Cardiac IKs (KCNQ1/KCNE1) Channels Regulation.International journal of molecular sciences · 2020Review
- Effects of protein-protein interactions and ligand binding on the ion permeation in KCNQ1 potassium channel.PloS one · 2018Article
- Molecular Pathophysiology of Congenital Long QT Syndrome.Physiological reviews · 2017Review
- Cardiac Delayed Rectifier Potassium Channels in Health and Disease.Cardiac electrophysiology clinics · 2016Review
- Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.Journal of molecular and cellular cardiology · 2014Article
- Up-regulation of Kv7.1 channels in thromboxane A2-induced colonic cancer cell proliferation.Pflugers Archiv : European journal of physiology · 2014Article
- Functional expression of KCNQ (Kv7) channels in guinea pig bladder smooth muscle and their contribution to spontaneous activity.British journal of pharmacology · 2013Article
- Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks).Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry.The Journal of physiology · 2011Article
- Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk.British journal of pharmacology · 2011Review
- Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase.Pflugers Archiv : European journal of physiology · 2009Article
- Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle.Pflugers Archiv : European journal of physiology · 2009Article
- Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels.The Journal of biological chemistry · 2008Article
- KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus laevis embryos.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2008Article
- Slow delayed rectifier potassium current (IKs) and the repolarization reserve.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2007Review
- Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.Pflugers Archiv : European journal of physiology · 2005Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The chromanol derivative 293B was previously shown to inhibit a cAMP regulated K+ conductance in rat colon crypts. Subsequent studies on cloned K+ channels from the rat demonstrated that 293B blocks specifically IsK channels expressed in Xenopus oocytes, but does not affect the delayed and inward rectifier Kv1.1 and Kir2.1, respectively. In the present study, the specificity of 293B for the cardiac K+ conductances IKs and IKr, and for the cloned guinea pig IsK channel and the human HERG channel, which underly IKs and IKr, respectively, was analyzed. 293B inhibited both the slowly activating K+ conductance IKs in cardiac myocytes and guinea pig IsK channels expressed in Xenopus oocytes with a similar IC50 (2-6 micromol/l). In contrast, high concentrations of 293B had only a negligible effect on the more rapid activating IKr. Similarly, 293B exerted no effect on HERG channels expressed in Xenopus oocytes. In summary, 293B appears to be a rather specific inhibitor of IKs and the underlying IsK channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.