ArticlePflugers Archiv : European journal of physiology1996
Activation kinetics of glutamate receptor channels from wild-type Drosophila muscle.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The gating properties of Drosophila NMJ glutamate receptors and their dependence on Neto.The Journal of physiology · 2024Article
- Neto proteins differentially modulate the gating properties ofbioRxiv : the preprint server for biology · 2024Article
- Versatile Endogenous Editing of GluRIIA inCells · 2024Article
- Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Effect of ambient extracellular glutamate on Drosophila glutamate receptor trafficking and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Article
- Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants.BMC biology · 2005Article
- Differential regulation of active zone density during long-term strengthening of Drosophila neuromuscular junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Role of cAMP cascade in synaptic stability and plasticity: ultrastructural and physiological analyses of individual synaptic boutons in Drosophila memory mutants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Desensitization and resensitization kinetics of glutamate receptor channels from Drosophila larval muscle.Biophysical journal · 1997Article
- Neuromuscular glutamatergic and GABAergic channels.Invertebrate neuroscience : INReview
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Authors and funding
3 authors.
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Abstract
Outside-out patches from wild-type Drosophila larval muscle were exposed briefly to L-Glutamate (Glu) using a piezo-driven application system. Glu in concentrations of 0.1 to 30 mM was applied and the responses to repeated applications of a given concentration were averaged. The peak current, î, and the current rise time, tr, from 0.1 î to 0.9 î were determined from the averages. Half-maximum activation of the channels was reached with approximately 2 mM Glu. î increased proportional to the power n = 3. 5 to n = 5.8 (average of four experiments, n = 4.4) for Glu concentrations between 0.3 and 0.5 mM. tr increased from approximately 0.2 ms at 10 mM Glu to a value of approximately 3.5 ms at 0.2 mM Glu. A linear reaction scheme with five binding steps preceding the channel-opening conformational change is proposed as the kinetic mechanism of channel activation and investigated in computer simulations. A set of rate constants assuming the same affinity for each binding site is found to describe the data better than one assuming positive cooperativity. The results are very similar to those for Glu-gated channels of crayfish and locust muscle, which is evidence for a common kinetic mechanism of these channels.
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