ArticleImmunogenetics1996
Allelic repertoire of the human MHC class I MICA gene.
Article in Immunogenetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 160 citations in OpenAlex.
- Trial
- Review
- Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation.Blood advances · 2023Article
- High-ThroughputFrontiers in immunology · 2020Article
- Article
- Article
- A new MHC-linked susceptibility locus for primary Sjögren's syndrome: MICA.Human molecular genetics · 2017Article
- Clinical significance of SNP (rs2596542) in histocompatibility complex class I-related gene A promoter region among hepatitis C virus related hepatocellular carcinoma cases.Journal of advanced research · 2017Article
- Major Histocompatibility Complex Class I Chain-Related A (MICA) Molecules: Relevance in Solid Organ Transplantation.Frontiers in immunology · 2017Review
- MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?Frontiers in immunology · 2017Review
- Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania.Autoimmune and infectious diseases : open access · 2016Article
- The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA.Immunogenetics · 2016Article
- MICA variant promotes allosensitization after kidney transplantation.Journal of the American Society of Nephrology : JASN · 2013Article
- Sequencing and comparative analysis of the gorilla MHC genomic sequence.Database : the journal of biological databases and curation · 2013Article
- Correlation of major histocompatibility complex class I related A (MICA) polymorphism with the risk of developing breast cancer.Medical oncology (Northwood, London, England) · 2012Article
- An NKG2D-mediated human lymphoid stress surveillance response with high interindividual variation.Science translational medicine · 2011Article
- Regulation of immune cell function and differentiation by the NKG2D receptor.Cellular and molecular life sciences : CMLS · 2011Review
- Role of major histocompatibility complex class I-related molecules A*A5.1 allele in ulcerative colitis in Chinese patients.Immunology · 2009Article
- Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.Arthritis research & therapy · 2009Article
- Structurally based epitope analysis of major histocompatibility complex class I-related chain A (MICA) antibody specificity patterns.Human immunology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassical MHC class I genes. A distinct family of MHC class I genes has been recently identified within the human MHC class I region. The MICA (MHC class I chain-related A) gene in this family is a highly divergent member of the MHC class I family and has a unique pattern of tissue expression. We have sequenced exons encoding the extracellular alpha1, alpha2, and alpha3 domains of the MICA gene from twenty HLA homozygous typing cell lines and four unrelated individuals. We report the identification of eleven new alleles defined by a total of twenty-two amino acid substitutions. Thus, the total number of MICA alleles is sixteen. Interestingly, a tentative superimposition of MICA variable residues on the HLA-A2 structure reveals a unique pattern of distribution, concentrated primarily on the outer edge of the MICA putative antigen binding cleft, apparently bordering an invariant ligand binding site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.