ArticleThe American journal of pathology1996
Tenascin-C and human tendon degeneration.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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Who cites it
47 citing papers in PubMed, 115 citations in OpenAlex.
- Thickness-Tunable Bilayer PBAT Nanofibrous Scaffolds for Enhancing r-AdMSCs' Tenogenic Commitment in Supraspinatus Tendon Regeneration.Journal of functional biomaterials · 2026Article
- Grafts in tendon repair.Materials today. Bio · 2026Review
- State-of the-art and future perspective in co-culture systems for tendon engineering.Biomaterials and biosystems · 2025Article
- Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies.Frontiers in bioengineering and biotechnology · 2023Review
- Tendon Cells Root Into (Instead of Attach to) Humeral Bone Head via Fibrocartilage-Enthesis.International journal of biological sciences · 2023Article
- TGF-β2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing.Stem cell research & therapy · 2022Article
- Article
- A decellularized flowable placental connective tissue matrix supports cellular functions of human tenocytes in vitro.Journal of experimental orthopaedics · 2022Article
- Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Therapeutic Effects of Platelet-Derived Extracellular Vesicles in a Bioengineered Tendon Disease Model.International journal of molecular sciences · 2022Article
- Craniofacial tendon development-Characterization of extracellular matrix morphology and spatiotemporal protein distribution.Frontiers in cell and developmental biology · 2022Article
- Serum deprivation limits loss and promotes recovery of tenogenic phenotype in tendon cell culture systems.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Low serum vitamin BBMC musculoskeletal disorders · 2021Article
- Extracellular matrix at the muscle - tendon interface: functional roles, techniques to explore and implications for regenerative medicine.Connective tissue research · 2021Review
- Differentially Expressed Proteins in Intra Synovial Compared to Extra Synovial Flexor Tendon Grafts in a Rabbit Tendon Transplantation Model.Biomedicines · 2020Article
- In Vitro Innovation of Tendon Tissue Engineering Strategies.International journal of molecular sciences · 2020Review
- Matrix regeneration proteins in the hypoxia-triggered exosomes of shoulder tenocytes and adipose-derived mesenchymal stem cells.Molecular and cellular biochemistry · 2020Article
- Lateral slit delivery of bone marrow stromal cells enhances regeneration in the decellularized allograft flexor tendon.Journal of orthopaedic translation · 2019Article
- A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta.Scientific reports · 2019Article
- TGFβ2-induced tenogenesis impacts cadherin and connexin cell-cell junction proteins in mesenchymal stem cells.Biochemical and biophysical research communications · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the distribution of tenascin in supraspinatus tendons to determine whether an alteration in tenascin expression was associated with human tendon degeneration. Tenascin was present in all of the tendons studied, although with two distinct patterns of expression. First, tenascin was associated with organized, fibrous regions of the tendon matrix that were typical of the normal tendon structure. This distribution is consistent with a role for tenascin in collagen fibril organization, perhaps maintaining the interface between fibrils and adjacent structures. Second, although tenascin was generally absent from poorly organized matrix in degenerate tendons, it was strongly associated with some rounded cells in disorganized fibrocartilaginous regions that were more abundant in pathological specimens. Tenascin was also found around infiltrating blood vessels, with more intense staining associated with a mononuclear cell infiltrate. Western blotting of tendon extracts showed differences in tenascin isoform expression, with only the small (200-kd) tenascin isoform found in normal tendons. Degenerate tendons also expressed the 300-kd isoform, consistent with a role for the larger tenascin isoform in tendon disease, potentially stimulating tenocyte proliferation, cell rounding, and fibrocartilaginous change. Proteolytic fragments of tenascin were detected but only in ruptured tendons, an indication of matrix remodeling in degenerate tendons, with fragment sizes consistent with the activity of matrix metalloproteinase enzymes.
Indexed as
Identifiers
8780397PMC1865170W1810967695What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.