ArticleThe American journal of pathology1996
Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 168 citations in OpenAlex.
- Loss of NF1 Accelerates Uveal and Intradermal Melanoma Tumorigenesis, and Oncogenic GNAQ Transforms Schwann Cells.Cancer research communications · 2025Article
- De novo identification of expressed cancer somatic mutations from single-cell RNA sequencing data.Genome medicine · 2023Article
- Review
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- Novel insights into the pathogenesis and treatment of NRAS mutant melanoma.Expert review of precision medicine and drug development · 2021Article
- Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated.Journal of translational medicine · 2020Article
- NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand.Oncotarget · 2016Article
- The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4.Cell cycle (Georgetown, Tex.) · 2016Article
- MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma.The American Journal of dermatopathology · 2015Article
- Genetics of melanocytic nevi.Pigment cell & melanoma research · 2015Review
- The immune-related role of BRAF in melanoma.Molecular oncology · 2015Article
- Oncogenic codon 13 NRAS mutation in a primary mesenchymal brain neoplasm and nevus of a child with neurocutaneous melanosis.Acta neuropathologica communications · 2014Article
- Association between BRAFV600E and NRASQ61R mutations and clinicopathologic characteristics, risk factors and clinical outcome of primary invasive cutaneous melanoma.Cancer causes & control : CCC · 2014Article
- Genetics of melanoma.Frontiers in genetics · 2012Article
- Article
- The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin.Pigment cell & melanoma research · 2011Review
- Molecular pathogenesis of sporadic melanoma and melanoma-initiating cells.Archives of pathology & laboratory medicine · 2010Review
- Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma.Experimental cell research · 2010Article
- Applications of genomics in melanoma oncogene discovery.Hematology/oncology clinics of North America · 2009Review
- Genetics and genomics of melanoma.Expert review of dermatology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intermittent or recreational exposure to sunlight is thought to contribute to development of human cutaneous melanoma. We investigated the incidence of ras oncogene mutation in human cutaneous melanoma in connection to sun-exposed body sites in the patient, using a large series of DNA samples derived from paraffin-embedded material as well as from fresh tumor samples and cell lines. We first show that, of the ras family, predominantly N-ras is activated (15%), whereas rarely H-ras or K-ras are mutated. The occurrence of N-ras mutations correlates with continuous exposure to sunlight of the primary tumor site. Of all tumors initiated on chronically sun-exposed body sites, 26% contained mutated N-ras, in contrast to 0% of sun-protected melanomas. Melanoma lesions obtained from patients from North or Central Europe contained fewer N-ras mutations (12%) as compared with patients from Australia (24%). Mutations were specifically associated with nodular melanoma and to a lesser extent with lentigo malignant melanoma. N-ras mutations did not correlate with metastasis or survival parameters. This study identifies a subset of cutaneous melanomas that contain in the primary lesion ultraviolet-induced N-ras mutations, which are maintained through further progression.
Indexed as
Identifiers
8780392PMC1865150W1519355090What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.