Evidence map›Paper›PMID 8778210›Full record

ReviewImmunologic research1995

Conformational changes induced in the MHC class I molecule by peptide and beta 2-microglobulin.

J C Solheim, J R Cook, T H Hansen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. T cell receptor interactions with class I heavy-chain influence T cell selection.Proceedings of the National Academy of Sciences of the United States of America · 2000
    Article
  4. Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.Proceedings of the National Academy of Sciences of the United States of America · 1999
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J C SolheimDepartment of Genetics, Washington University School of Medicine, St. Louis, Mo., USA.
J R Cook
T H Hansen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with beta 2-microglobulin (beta 2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule folds and begins its sojourn to the cell surface. To maintain its folded conformation, class I MHC requires peptide but not beta 2m, and the sequence of the peptide bound exercises a subtle influence on the structure of the class I molecule that is likely to be a factor in T cell receptor discrimination of MHC/peptide complexes.

Indexed as

AnimalsAntigen Presentationbeta 2-MicroglobulinCalcium-Binding ProteinsCalnexinHistocompatibility Antigens Class IMiceModels, ImmunologicalModels, MolecularPeptidesProtein ConformationProtein Foldingbeta 2-MicroglobulinCalcium-Binding ProteinsCalnexinHistocompatibility Antigens Class IPeptides

Identifiers

PMID8778210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.