ArticleHeart (British Cardiac Society)1996
Increased serum concentrations of interleukin-1 beta in patients with coronary artery disease.
Article in Heart (British Cardiac Society), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 87 citations in OpenAlex.
- Association of testosterone-induced increase in neutrophil and monocyte counts with thromboembolic events: The TRAVERSE trial.American heart journal · 2025Trial
- Role of interleukins in the pathogenesis of coronary heart disease: A literature review.World journal of cardiology · 2025Review
- NASH triggers cardiometabolic HFpEF in aging mice.GeroScience · 2024Article
- Association between Inflammation and New-Onset Atrial Fibrillation in Acute Coronary Syndromes.Journal of clinical medicine · 2024Review
- Central regulation of stress-evoked peripheral immune responses.Nature reviews. Neuroscience · 2023Review
- Correlation of miR-24-3p and miR-595 expression withEXCLI journal · 2022Article
- Detoxification of Bee Venom Increases Its Anti-inflammatory Activity and Decreases Its Cytotoxicity and Allergenic Activity.Applied biochemistry and biotechnology · 2021Article
- Age and Interleukin-15 Levels Are Independently Associated With Intima-Media Thickness in Obesity-Related NAFLD Patients.Frontiers in medicine · 2021Article
- Evaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease.Sensors (Basel, Switzerland) · 2019Review
- Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO.Frontiers in physiology · 2018Review
- Interleukin-1β (IL-1β) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein δ (C/EBPδ) expression in hepatocytes.The Journal of biological chemistry · 2017Article
- An epoxyisoprostane is a major regulator of endothelial cell function.Journal of medicinal chemistry · 2013Article
- IL-1 receptor 2 (IL-1R2) and its role in immune regulation.Brain, behavior, and immunity · 2013Review
- Post-infarct remodelling: contribution of wound healing and inflammation.Cardiovascular research · 2009Review
- Beneficial effects of cardiac rehabilitation and exercise after percutaneous coronary intervention on hsCRP and inflammatory cytokines in CAD patients.Pflugers Archiv : European journal of physiology · 2008Article
- Cardiovascular diabetology in the core of a novel interleukins classification: the bad, the good and the aloof.Cardiovascular diabetology · 2003Article
- Systemic response of peripheral blood leukocytes and their phagocytic activity during acute myocardial infarction.Experimental and clinical cardiology · 2001Article
- Circulating levels of IL-1beta, a prothrombotic cytokine, are elevated in unstable angina versus stable angina.Journal of thrombosis and thrombolysis · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess serum interleukin-1 beta (IL-1 beta) concentrations in patients with ischaemic heart disease, to characterise subgroups of patients with raised IL-1 beta concentrations, and to examine whether serum IL-1 beta concentrations correlate with non-specific indices of inflammation.
designSurvey study of patients with ischaemic heart disease.
settingCardiac catheterisation laboratory of a tertiary medical centre. PATIENTS: Consecutive patients with angina pectoris and patients recovering from uncomplicated acute myocardial infarction and undergoing elective coronary angiography.
resultsMean(SD) serum IL-1 beta concentrations were higher (P < 0.001) in patients with angina and < 50% coronary artery stenosis (n = 11; 18.8(19.9) pg/ml), patients with angina > or = 50% stenosis (n = 23; 10.2(11.4) pg/ml), and patients 8(0.8) days post-infarction (n = 13; 4.4(5.8) pg/ml) than in 15 healthy, age-matched controls (0.3(0.5) pg/ml). Serum IL-1 beta concentrations did not correlate with total blood leucocyte counts (r = -0.07, P = NS), blood lymphocyte counts (r = -0.24, P = NS), and blood monocyte counts (r = -0.29, P = NS), or with fibrinogen (r = -0.16, P = NS) and C-reactive protein concentrations (9(10.5) mg/dl v 14.1(19) mg/dl for patients with undetectable and detectable concentrations, respectively, P = NS).
conclusionSerum IL-1 beta concentrations are raised in patients with ischaemic heart disease, in particular in those with minimal coronary artery disease and angina. The precise role of IL-1 beta in coronary artery disease remains to be determined.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.