ArticleAnnals of the rheumatic diseases1996
Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 105 citations in OpenAlex.
- Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis.Arthritis research & therapy · 2023Article
- Apoptosis Regulation in Osteoarthritis and the Influence of Lipid Interactions.International journal of molecular sciences · 2023Review
- Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis.Scientific reports · 2022Article
- The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes.Immunologic research · 2021Review
- Avenues to molecular imaging of dying cells: Focus on cancer.Medicinal research reviews · 2018Review
- CIP2A facilitates apoptotic resistance of fibroblast-like synoviocytes in rheumatoid arthritis independent of c-Myc expression.Rheumatology international · 2013Article
- Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide.Experimental & molecular medicine · 2010Article
- BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.Oncogene · 2008Review
- Expression of heat shock protein receptors on fibroblast-like synovial cells derived from rheumatoid arthritis-affected joints.Rheumatology international · 2008Article
- Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis.Arthritis research & therapy · 2008Article
- Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis.Arthritis research & therapy · 2007Article
- Local cell proliferation in rheumatoid synovial tissue: analysis by cyclin expression.Clinical rheumatology · 2006Article
- Human immunodeficiency virus vector-mediated intra-articular expression of angiostatin inhibits progression of collagen-induced arthritis in mice.Rheumatology international · 2005Article
- Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study.Arthritis research & therapy · 2004Article
- A proinflammatory role for Fas in joints of mice with collagen-induced arthritis.Arthritis research & therapy · 2004Article
- p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion.Annals of the rheumatic diseases · 2003Article
- Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.The American journal of pathology · 2003Article
- The role of osteoprotegerin in arthritis.Arthritis research & therapy · 2003Review
- Mediators of inflammation are down-regulated while apoptosis is up-regulated in rheumatoid arthritis synovial tissue by polymerized collagen.Clinical and experimental immunology · 2002Article
- The stressed synovium.Arthritis research · 2001Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether apoptosis occurs in the synovium of rheumatoid arthritis (RA), and the intermediate molecules operating in this process.
methodsDNA fragmentation was detected by in situ nick end labelling (ISNEL) in the synovium of patients with RA (n = 11) and control patients with femoral neck fracture (n = 5). The expression of proteins p53, p21WAFI/CIPI, c-myc, proliferating cell nuclear antigen (PCNA), and Bcl-2 was also examined by immunohistochemistry.
resultsISNEL positive synovial cells with apoptosis specific morphology were detected in extremely limited areas in only two RA synovial tissue specimens. Proteins p53, p21WAFI/CIPI, and c-myc, known inducers of apoptosis or cell cycle arrest or both, were expressed in the sublining cells independent of ISNEL positive cells. PCNA, a marker for cell proliferation, was observed in the synovial lining cells. Bcl-2, an inhibitor of apoptosis, was expressed mainly in infiltrated lymphocytes and in parts of the sublining layer cells of RA; it also did not correspond with ISNEL staining.
conclusionsOur findings indicate that RA synovial cells undergo apoptosis in addition to cell proliferation, but the frequency of apoptosis was very low. We suspect that the apoptotic process in the RA synovium may be suppressed by over-expression of Bcl-2. Although expressed proteins p53, p21WAFI/CIPI, and c-myc were present in the RA synovium, these protooncogenes are probably not implicated in the apoptotic process.
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