ArticleThe American journal of pathology1996
Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells.Acta neuropathologica communications · 2026Article
- Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours.The journal of pathology. Clinical research · 2023Review
- Neurotrophin Signaling in Medulloblastoma.Cancers · 2020Review
- Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma.Frontiers in pharmacology · 2019Article
- BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells.Journal of molecular neuroscience : MN · 2016Article
- Induction of hypoxia-inducible factor-1α by BDNF protects retinoblastoma cells against chemotherapy-induced apoptosis.Molecular and cellular biochemistry · 2016Article
- CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.PloS one · 2013Article
- Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway.PloS one · 2010Article
- BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cells.Journal of molecular neuroscience : MN · 2010Article
- Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes.International journal of cancer · 2009Article
- Recent advances in embryonal tumours of the central nervous system.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2005Review
- Expression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma.Journal of biosciences · 2003Article
- Nerve growth factor plays a divergent role in mediating growth of rat C6 glioma cells via binding to the p75 neurotrophin receptor.Journal of neuro-oncology · 2002Article
- Up-regulation of insulin-like growth factor-II expression is a feature of TrkA but not TrkB activation in SH-SY5Y neuroblastoma cells.The American journal of pathology · 1999Article
- The interaction of neurotrophins with the p75NTR common neurotrophin receptor: a comprehensive molecular modeling study.Protein science : a publication of the Protein Society · 1999Article
- Gangliosides and neutral glycolipids in ependymal, neuronal and primitive neuroectodermal tumors.Journal of molecular neuroscience : MN · 1999Article
- Primitive neuroectodermal tumors of the central nervous system.Brain pathology (Zurich, Switzerland) · 1997Review
- Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Effects of basic fibroblastic growth factor on the growth of human medulloblastoma xenografts.Journal of neuro-oncologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS) are poorly understood childhood neoplasms, and medulloblastomas are the most common pediatric PNETs. Neoplastic cells in medulloblastomas and other PNETs resemble progenitor cells of the developing central nervous system, but they also may exhibit the molecular phenotype of immature neurons or glia. As neurotrophins play a role in regulating differentiation, proliferation, and cell death in the normal developing central nervous system, and recent evidence suggests that neurotrophins may influence the behavior of medulloblastomas, we studied 29 PNET biopsy samples (27 of which were posterior fossa medulloblastomas) by immunobistochemistry using antibodies specific for each of the major high affinity neurotrophin receptor proteins, ie, TrkA, TrkB, and TrkC. A subset of these tumors also was examined by Western blot. Immunoreactive TrkA, TrkB, and TrkC were observed in neoplastic cells in 8 (27%), 18 (62%), and 14 (48%) of these PNETs, respectively. Additional immunohistochemical studies of a subset of these PNETs using antibodies to neurotrophins that primarily activate TrkB and TrkC, ie, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5, showed that immunoreactive brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 were detected in 22, 9, and 19% of these PNET biopsies, respectively. Finally, 19 pediatric brain tumors other than these PNETs also were studied here, and they expressed these neurotrophins and their receptors to a variable extent. The demonstration here that neurotrophins and their cognate receptor proteins are expressed in PNETs as well as in other pediatric brain tumors may imply that signal transduction pathways mediated by neurotrophins and/or their receptors influence the induction or progression of these common childhood neoplasms.
Indexed as
Identifiers
8774147PMC1861715W274031538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.