ArticleThe American journal of pathology1996
Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 81 citations in OpenAlex.
- Phenotype and function of tumor-associated neutrophils and their subsets in early-stage human lung cancer.Cancer immunology, immunotherapy : CII · 2017Review
- Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor.British journal of pharmacology · 2012Article
- Global gene expression profile progression in Gaucher disease mouse models.BMC genomics · 2011Article
- Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice.ASN neuro · 2009Article
- Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata.Clinical and experimental immunology · 2004Article
- Response of chemokine antagonists to inflammation in injured spinal cord.Neurochemical research · 2003Review
- Article
- Contrasting roles for RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in a murine model of allergic peritonitis.Clinical and experimental immunology · 1999Article
- Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection.The American journal of pathology · 1997Article
- Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro.The Journal of experimental medicine · 1997Article
- Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis.The American journal of pathology · 1996Article
- Chemokine receptors and T cell chemotaxis.The Journal of experimental medicine · 1996Article
- Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.The Journal of experimental medicine · 1996Article
- Chemokines and the pathogenesis of T cell-dependent immune responses.The American journal of pathology · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Leukocytes express chemokine receptors that, upon ligand recognition, are believed to activate and induce the directed migration of these cells from the vasculature to sites of tissue injury. Previous investigations of human and animal inflammatory tissue have revealed that expression of chemokines can be increased in association with leukocyte infiltration. Monocyte chemotactic protein-1 (MCP-1) mediates monocyte chemotaxis in vitro and migration of monocytes to inflammatory sites in vivo. More recently T cell chemotaxis to MCP-1 has been observed in vitro, but the contribution of this protein to T cell migration in vivo and to lymphocyte-mediated inflammation has not been determined. In this report, we show that using a rat model of cutaneous delayed hypersensitivity, MCP-1 expression correlates spatially and kinetically with T cell and monocyte recruitment and that antibodies directed to MCP-1 when administered therapeutically to animals undergoing delayed hypersensitivity can almost completely abolish T cell migration and inflammatory sequelae. Moreover the concentration of antibody needed to inhibit T cell trafficking to inflammatory sites is almost on order of magnitude lower than that needed to impede monocyte recruitment. Therefore, MCP-1 is functionally relevant in the genesis of delayed hypersensitivity and may be a useful therapeutic target for diseases mediated in part by T lymphocytes.
Indexed as
Identifiers
8774140PMC1861724W131220403What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.