ArticleThe American journal of pathology1996
Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 85 citations in OpenAlex.
- Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- FXR deletion attenuates intestinal barrier dysfunction in murine acute intestinal inflammation.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Development of a Gut-On-A-Chip Model for High Throughput Disease Modeling and Drug Discovery.International journal of molecular sciences · 2019Article
- Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels.The Journal of pathology · 2019Article
- The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell Carcinoma.PloS one · 2016Article
- Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon.Biological chemistry · 2012Article
- Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function.Digestive diseases and sciences · 2011Article
- Differential distributions of CSE1L/CAS and E-cadherin in the polarized and non-polarized epithelial glands of neoplastic colorectal epithelium.Journal of molecular histology · 2010Article
- Recombinant human elafin protects airway epithelium integrity during inflammation.Molecular biology reports · 2010Article
- Hereditary diffuse gastric cancer: a manifestation of lost cell polarity.Cancer science · 2009Review
- Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury.American journal of respiratory cell and molecular biology · 2009Review
- Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function.American journal of physiology. Cell physiology · 2009Article
- Relationship between beta-catenin expression and epithelial cell proliferation in gastric mucosa with intestinal metaplasia.World journal of gastroenterology · 2005Article
- Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue.Journal of clinical pathology · 2001Article
- Effects of cigarette smoke extract on E-cadherin expression in cultured airway epithelial cells.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 2000Article
- Expression of syndecan-1 in inflammatory bowel disease and a possible mechanism of heparin therapy.Digestive diseases and sciences · 1999Article
- Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The role of adhesion molecules in gastric ulcer healing.World journal of gastroenterology · 1998Article
- Modulation of epithelial cell adhesion in gastrointestinal homeostasis.The American journal of pathology · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
E-cadherin, an epithelial adhesion molecule, is critical for the maintenance of cell polarity and differentiation. We studied the distribution of E-cadherin in normal gut and in enteric ulceration to test the hypothesis that the motility of regenerative epithelium over ulcers is associated with a decrease in E-cadherin expression. Sections of normal stomach, small intestine, and colon were examined for E-cadherin distribution using the antibody HECD-1 and compared with the pattern seen in peptic ulceration and Crohn's disease. A subset was examined by in situ hybridization using 35S radiolabeled E-cadherin riboprobes. A wounding system employing the HT-29 cell line was used as an in vitro model of early healing. In the normal gut uniform strong basolateral staining was seen. Areas of ulceration showed a patchy reduction in membrane localized E-cadherin in regenerating epithelium, even though E-cadherin mRNA was demonstrable in this population. In wounded confluent HT29 layers, migrating cells also showed reduced E-cadherin immunostaining. These data support the notion that the motility of restitutive epithelial cells may relate to altered patterns of E-cadherin and that this may play an important role in the reconstitution of epithelial integrity after mucosal injury.
Indexed as
Identifiers
8774128PMC1861718W68177541What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.