ArticleThe American journal of pathology1996
Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 76 citations in OpenAlex.
- The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.Molecular and cellular biology · 2022Trial
- Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome.BMC pulmonary medicine · 2019Article
- Deficient Follistatin-like 3 Secretion by Asthmatic Airway Epithelium Impairs Fibroblast Regulation and Fibroblast-to-Myofibroblast Transition.American journal of respiratory cell and molecular biology · 2018Article
- Follistatin and the Breast Implant Capsule.Plastic and reconstructive surgery. Global open · 2017Article
- Effects of the Activin A-Follistatin System on Myocardial Cell Apoptosis through the Endoplasmic Reticulum Stress Pathway in Heart Failure.International journal of molecular sciences · 2017Article
- Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF.Immunology and cell biology · 2016Article
- Activins and Inhibins: Roles in Development, Physiology, and Disease.Cold Spring Harbor perspectives in biology · 2016Review
- The immunoregulatory and fibrotic roles of activin A in allergic asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Review
- Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models.BMC pulmonary medicine · 2014Article
- Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection.BMC infectious diseases · 2014Observational
- Follistatin, an activin antagonist, ameliorates renal interstitial fibrosis in a rat model of unilateral ureteral obstruction.BioMed research international · 2014Article
- Activin, neutrophils, and inflammation: just coincidence?Seminars in immunopathology · 2013Review
- Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25.American journal of respiratory and critical care medicine · 2010Article
- Role of activins and inducible nitric oxide in the pathogenesis of ectopic pregnancy in patients with or without Chlamydia trachomatis infection.Clinical and vaccine immunology : CVI · 2009Article
- Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.British journal of cancer · 2005Article
- Induction of prostanoid, nitric oxide, and cytokine formation in rat bone marrow derived macrophages by activin A.British journal of pharmacology · 1999Article
- Immunohistochemical localisation of advanced glycation end products in pulmonary fibrosis.Journal of clinical pathology · 1998Article
- Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.The Journal of clinical investigation · 1997Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of activin A, one of the transforming growth factor-beta supergene family, was studied in various pulmonary conditions associated with interstitial pulmonary fibrosis (3 cases with diffuse alveolar damage, 6 cases with idiopathic pulmonary fibrosis, and 1 case with pulmonary fibrosis associated with rheumatoid arthritis) using immunohistochemical techniques on paraffin-embedded sections. Controls consisted of 10 cases with normal pulmonary parenchyma, and 2 cases with primary pulmonary hypertension and 1 case with secondary pulmonary hypertension were also studied. The lung specimens from normal parenchyma weakly expressed immunoreactive activin A on the bronchiolar epithelium. In marked contrast, all of the specimens from cases with diffuse alveolar damage and interstitial pulmonary fibrosis demonstrated strong expression of activin A on metaplastic epithelium, hyperplastic smooth muscle cells, desquamated cells, and alveolar macrophages. Pulmonary arteries from patients with primary or secondary pulmonary hypertension showed abundant immunoreactive activin A on smooth muscle cells. These findings suggest a potential role for this growth factor, activin A, in the pathogenesis of pulmonary tissue remodeling associated with interstitial pulmonary fibrosis.
Indexed as
Identifiers
8774126PMC1861725W1725422135What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.