ArticleThe American journal of pathology1996
Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 64 citations in OpenAlex.
- PEG-coated nanoparticles detachable in acidic microenvironments for the tumor-directed delivery of chemo- and gene therapies for head and neck cancer.Theranostics · 2020Article
- Identification of anti-cancer chemical compounds using Xenopus embryos.Cancer science · 2016Article
- The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma.Oncotarget · 2014Article
- Overexpression of ETV4 protein in triple-negative breast cancer is associated with a higher risk of distant metastasis.OncoTargets and therapy · 2014Article
- Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation.Cellular microbiology · 2014Article
- Analysis of select members of the E26 (ETS) transcription factors family in colorectal cancer.Virchows Archiv : an international journal of pathology · 2011Article
- HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium.British journal of cancer · 2011Article
- HuR is exported to the cytoplasm in oral cancer cells in a different manner from that of normal cells.British journal of cancer · 2009Article
- nm23-H1 suppresses invasion of oral squamous cell carcinoma-derived cell lines without modifying matrix metalloproteinase-2 and matrix metalloproteinase-9 expression.The American journal of pathology · 2001Article
- Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression.The American journal of pathology · 2000Article
- Analysis of mechanisms underlying BRMS1 suppression of metastasis.Clinical & experimental metastasis · 2000Article
- Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression.Oncogene · 1999Article
- Immunohistopathological characterizatin of spontaneous metastases in a human lung mucoepidermoid adenocarcinoma (HLMC) xenograft.Pathology oncology research : POR · 1998Article
- The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60.Nucleic acids research · 1997Article
- Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.The American journal of pathology · 1997Article
- Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities.The American journal of pathology · 1997Article
- Two transcription factors, E1AF and N-myc, correlate with the invasiveness of neuroblastoma cell lines.Japanese journal of cancer research : Gann · 1997Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinases (MMPs) have been implicated in invasion and metastasis of tumor cells. Transcription regulatory regions of MMP genes often contain binding sites for ets transcription factors. We recently isolated a cDNA encoding human E1A-F, a member of the ets oncogene family, and showed that E1A-F can upregulate MMP genes by CAT assay. We attempted to investigate the relationship between E1A-F mRNA expression and MMP protein expression in four different types of oral squamous-cell-carcinoma-derived cell lines (HSC 3, SAS, KB, and Ca 9.22). HSC 3 and SAS are highly invasive cell lines when they are injected in the tongue of nude mice. Raft culture of HSC 3 and SAS revealed the same characteristics as seen in tumors implanted in vivo. Both type I collagenase (MMP-1) and 92-kd type IV collagenase (MMP-9) were detected in cultured HSC 3 and SAS cells. E1A-F mRNA was demonstrated to be highly expressed in HSC 3 and SAS by Northern blotting, and in situ hybridization confirmed E1A-F mRNA expression at the invasion front of tumor cells seeded on collagen gel. On the other hand, KB and Ca 9.22 have little potential for invasion, and MMP-1 and MMP-9 protein and E1A-F mRNA could not be detected. These results suggest that the ets-related E1A-F participates in the regulation of invasion-associated MMP genes and is involved in presenting invasive activity in tumor cells of oral squamous cell carcinoma.
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Identifiers
8774124PMC1861731W2143353959What OpenQuestion holds
Registered trials
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