ArticlePflugers Archiv : European journal of physiology1996
Different time courses of GTP[gamma-S]-induced exocytosis and current oscillations in isolated mouse pancreatic acinar cells.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Real-time studies of zymogen granule exocytosis in intact rat pancreatic acinar cells.The Journal of physiology · 2000Article
- Characterization of cell volume-sensitive chloride currents in freshly prepared and cultured pancreatic acinar cells from early postnatal rats.The Journal of physiology · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Exocytosis in isolated mouse pancreatic acinar cells was investigated using the dual-frequency method for measuring membrane capacitance and ionic conductances. Under control conditions, single exo- and endocytotic events could be resolved. The total cell capacitance slightly decreased to 98.7 +/- 0.9% of the initial cell capacitance within 10 min after establishing the whole-cell configuration. When guanosine 5'-O-(3-thiophosphate) (GTP[gamma-S] was added to the patch pipette, stepwise elevations in membrane capacitance occurred and the cell capacitance increased to 106.7 +/- 1.6% within 10 min. Exocytosis was also stimulated by GTP[gamma-S] when a Ca2+-free pipette solution supplemented with 1 to 10 mM ethylenebis(oxonitrilo) tetraacetate (EGTA) was used. Measurement of the DC current component in parallel with AC current analysis was used to isolate components of the Ca2+-dependent Cl- and monovalent cation conductances from the whole-cell conductance. These experiments demonstrate that in GTP[gamma-S]-stimulated pancreatic acinar cells: (1) activation of Cl- currents precedes that of cation currents, and (2) fusion of the zymogen granule membrane with the plasma membrane does not lead to incorporation of active Cl- or nonselective cation channels (>/= 10 pS).
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