ArticlePflugers Archiv : European journal of physiology1996
An endogenous inactivating inward-rectifying potassium current in oocytes of Xenopus laevis.
Article in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- HCN Channel Phosphorylation Sites Mapped by Mass Spectrometry in Human Epilepsy Patients and in an Animal Model of Temporal Lobe Epilepsy.Neuroscience · 2021Article
- Identification of a unique endoplasmic retention motif in the Xenopus GIRK5 channel and its contribution to oocyte maturation.FEBS open bio · 2021Article
- Ion channels and signaling pathways used in the fast polyspermy block.Molecular reproduction and development · 2020Review
- RNS60, a charge-stabilized nanostructure saline alters Xenopus Laevis oocyte biophysical membrane properties by enhancing mitochondrial ATP production.Physiological reports · 2015Article
- Article
- Extracellular potassium effects are conserved within the rat erg K+ channel family.The Journal of physiology · 2005Article
- The transoocyte voltage clamp: a non-invasive technique for electrophysiological experiments with Xenopus laevis oocytes.Pflugers Archiv : European journal of physiology · 2004Article
- The physiology and pharmacology of singlet oxygen.Medical hypotheses · 2003Article
- Mutation in pore domain uncovers cation- and voltage-sensitive recovery from inactivation in KAT1 channel.Biophysical journal · 2000Article
- The erg-like potassium current in rat lactotrophs.The Journal of physiology · 1999Article
- HERG-like K+ channels in microglia.The Journal of general physiology · 1998Article
- Idiosyncratic gating of HERG-like K+ channels in microglia.The Journal of general physiology · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An endogenous inward-rectifying K+ current is described, which is present in native oocytes of some Xenopus laevis donors. Experiments were performed using defolliculated oocytes from donor frogs obtained from two different suppliers. In all oocytes from animals from one source, an inward-rectifying K+ current could be elicited with negative pulses from a holding potential of -20 mV in external solutions with a high K+ concentration. Increasing external K+ concentrations increased the amplitude of this current and shifted the reversal potential towards more positive potentials. In 118 mM KCl, the inward-rectifying K+ current partially inactivated between -20 and -80 mV and completely inactivated at more negative membrane potentials; 50% steady-state inactivation occurred near -50 mV. The time course of inactivation of the inward-rectifying current could be well fitted with two exponentials. The slow time constant had values of about 500 ms and was voltage independent. In contrast, the fast time constant and the time to reach the peak inward current decreased with more negative membrane potentials. Ba2+, Cs+, quinine (all 5 mM) and 50 mM tetraethylammonium partially blocked the inward-rectifying K+ current, whereas 10 mM 4-aminopyridine was without blocking effect. The oxidant chloramine-T blocked the inward-rectifying K+ current without slowing its inactivation.
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