ArticleGenetics1996
Evolution of Antennapedia-class homeobox genes.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- What Has Genomics Taught An Evolutionary Biologist?Genomics, proteomics & bioinformatics · 2023Review
- Suboptimal Intermediates Underlie Evolution of the Bicoid Homeodomain.Molecular biology and evolution · 2021Article
- Anterior Hox Genes and the Process of Cephalization.Frontiers in cell and developmental biology · 2021Review
- Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals.BMC evolutionary biology · 2019Article
- A Conserved Structural Signature of the Homeobox Coding DNA in HOX genes.Scientific reports · 2016Article
- Diversification of four human HOX gene clusters by step-wise evolution rather than ancient whole-genome duplications.Development genes and evolution · 2015Review
- Functional divergence of gene duplicates - a domain-centric view.BMC evolutionary biology · 2012Article
- Statistics and truth in phylogenomics.Molecular biology and evolution · 2012Review
- Rapid evolution and copy number variation of primate RHOXF2, an X-linked homeobox gene involved in male reproduction and possibly brain function.BMC evolutionary biology · 2011Article
- The origin of patterning systems in bilateria-insights from the Hox and ParaHox genes in Acoelomorpha.Genomics, proteomics & bioinformatics · 2011Review
- Fragile regions and not functional constraints predominate in shaping gene organization in the genus Drosophila.Genome research · 2010Article
- Multiple chromosomal rearrangements structured the ancestral vertebrate Hox-bearing protochromosomes.PLoS genetics · 2009Article
- Are we degenerate tetraploids? More genomes, new facts.Biology direct · 2008Article
- Ultraconserved coding regions outside the homeobox of mammalian Hox genes.BMC evolutionary biology · 2008Article
- An insight into the phylogenetic history of HOX linked gene families in vertebrates.BMC evolutionary biology · 2007Article
- The new mutation theory of phenotypic evolution.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the sea anemone, Nematostella vectensis.PloS one · 2007Article
- The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensis.Genome biology · 2006Article
- Evidence for Hox gene duplication in rainbow trout (Oncorhynchus mykiss): a tetraploid model species.Journal of molecular evolution · 2005Article
- Evolutionary change of the numbers of homeobox genes in bilateral animals.Molecular biology and evolution · 2005Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antennapedia (Antp)-class homeobox genes are involved in the determination of pattern formation along the anterior-posterior axis of the animal embryo. A phylogenetic analysis of Antp-class homeodomains of the nematode, Drosophila, amphioxus, mouse, and human indicates that the 13 cognate group genes of this gene family can be divided into two major groups, i.e., groups I and II. Group I genes can further be divided into subgroups A (cognate groups 1-2), B (cognate group 3), and C (cognate groups 4-8), and group II genes can be divided into subgroups D (cognate groups 9-10) and E (cognate groups 11-13), though this classification is somewhat ambiguous. Evolutionary distances among different amino acid sequences suggest that the divergence between group I and group II genes occurred approximately 1000 million years (MY) ago, and the five different subgroups were formed by approximately 600 MY ago, probably before the divergence of Pseudocoelomates (e.g., nematodes) and Coelomates (e.g., insects and chordates). Our results show that the genes that are phylogenetically close are also closely located in the chromosome, suggesting that the colinearity between the gene expression and gene arrangement was generated by successive tandem gene duplications and that the gene arrangement has been maintained by some sort of selection.
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