ArticleGenetics1996
Potential RNA binding proteins in Saccharomyces cerevisiae identified as suppressors of temperature-sensitive mutations in NPL3.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 90 citations in OpenAlex.
- Defenders of the Transcriptome: Guard Protein-Mediated mRNA Quality Control inInternational journal of molecular sciences · 2024Review
- Characterization of the mIF4G Domains in the RNA Surveillance Protein Upf2p.Current issues in molecular biology · 2023Article
- Surveillance of 3' mRNA cleavage during transcription termination requires CF IB/Hrp1.Nucleic acids research · 2023Article
- Distinct Functions of the Cap-Binding Complex in Stimulation of Nuclear mRNA Export.Molecular and cellular biology · 2019Article
- Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1.Molecular microbiology · 2017Article
- Arginine methylation promotes translation repression activity of eIF4G-binding protein, Scd6.Nucleic acids research · 2016Article
- Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.PLoS genetics · 2015Article
- RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.Chemical reviews · 2013Review
- The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae.Journal of molecular biology · 2009Article
- Specific sequences within arginine-glycine-rich domains affect mRNA-binding protein function.Nucleic acids research · 2009Article
- Selection of yeast strains with enhanced expression of Plasmodium falciparum proteins.Molecular and biochemical parasitology · 2009Article
- A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast.Molecular cell · 2008Article
- Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export.The Journal of biological chemistry · 2008Article
- Autoregulation of Npl3, a yeast SR protein, requires a novel downstream region and serine phosphorylation.Molecular and cellular biology · 2008Article
- Snu56p is required for Mer1p-activated meiotic splicing.Molecular and cellular biology · 2008Article
- Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI.RNA (New York, N.Y.) · 2007Article
- An interaction between two RNA binding proteins, Nab2 and Pub1, links mRNA processing/export and mRNA stability.Molecular and cellular biology · 2007Article
- Protein arginine methylation in Candida albicans: role in nuclear transport.Eukaryotic cell · 2007Article
- Npl3 is an antagonist of mRNA 3' end formation by RNA polymerase II.The EMBO journal · 2005Article
- Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles.RNA (New York, N.Y.) · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NPL3 gene of the yeast Saccharomyces cerevisiae encodes a protein with similarity to heterogeneous nuclear ribonucleoproteins (hnRNPs). Npl3p has been implicated in many nuclear-related events including RNA export, protein import, and rRNA processing. Several temperature-sensitive alleles of NPL3 have been isolated. We now report the sequence of these alleles. For one allele, npl3-1, four complementation groups of suppressors have been isolated. The cognate genes for the two recessive mutants were cloned. One of these is the previously known RNA15, which, like NPL3, also encodes a protein with similarity to the vertebrate hnRNP A/B protein family. The other suppressor corresponds to a newly defined gene we term HRP1, which also encodes a protein with similarity to the hnRNP A/B proteins of vertebrates. Mutations in HRP1 suppress all npl3 temperature-sensitive alleles but do not bypass an npl3 null allele. We show that HRP1 is essential for cell growth and that the corresponding protein is located in the nucleus. The discovery of two hnRNP homologues that can partially suppress the function of Npl3p, also an RNA binding protein, will be discussed in terms of the possible roles for Npl3p in RNA metabolism.
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