ArticleBiophysical journal1996
Spectroscopic and molecular modeling studies of caffeine complexes with DNA intercalators.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 93 citations in OpenAlex.
- Computational analysis of the solvation of coffee ingredients in aqueous ionic liquid mixtures.RSC advances · 2017Article
- Turning an aptamer into a light-switch probe with a single bioconjugation.Bioconjugate chemistry · 2015Article
- Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules.European biophysics journal : EBJ · 2014Article
- Probing the interior of self-assembled caffeine dimer at various temperatures.Journal of fluorescence · 2012Article
- Complexation of biologically active aromatic compounds with DNA in the presence of theophylline.Journal of biological physics · 2009Article
- Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.Biophysical chemistry · 2008Article
- Complexation of anthracycline drugs with DNA in the presence of caffeine.European biophysics journal : EBJ · 2006Article
- Interactions of chlorophyllin with acridine orange, quinacrine mustard and doxorubicin analyzed by light absorption and fluorescence spectroscopy.Biophysical chemistry · 2003Article
- Attenuation of cytotoxic natural product DNA intercalating agents by caffeine.Scientia pharmaceuticaArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated that caffeine can act as an antimutagen and inhibit the cytoxic and/or cytostatic effects of some DNA intercalating agents. It has been suggested that this inhibitory effect may be due to complexation of the DNA intercalator with caffeine. In this study we employ optical absorption, fluorescence, and molecular modeling techniques to probe specific interactions between caffeine and various DNA intercalators. Optical absorption and steady-state fluorescence data demonstrate complexation between caffeine and the planar DNA intercalator acridine orange. The association constant of this complex is determined to be 258.4 +/- 5.1 M-1. In contrast, solutions containing caffeine and the nonplanar DNA intercalator ethidium bromide show optical shifts and steady-state fluorescence spectra indicative of a weaker complex with an association constant of 84.5 +/- 3.5 M-1. Time-resolved fluorescence data indicate that complex formation between caffeine and acridine orange or ethidium bromide results in singlet-state lifetime increases consistent with the observed increase in the steady-state fluorescence yield. In addition, dynamic polarization data indicate that these complexes form with a 1:1 stoichiometry. Molecular modeling studies are also included to examine structural factors that may influence complexation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.