ArticleBiophysical journal1996
An elastic network model based on the structure of the red blood cell membrane skeleton.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 114 citations in OpenAlex.
- Cellular Blood Flow Modeling with HemoCell.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Effective cell membrane tension protects red blood cells against malaria invasion.PLoS computational biology · 2023Article
- Detection of Single Molecules Using Stochastic Resonance of Bistable Oligomers.Nanomaterials (Basel, Switzerland) · 2020Article
- A novel strain energy relationship for red blood cell membrane skeleton based on spectrin stiffness and its application to micropipette deformation.Biomechanics and modeling in mechanobiology · 2016Article
- Large Deformation Properties of Red Blood Cell Membrane Based on a Higher Order Gradient Quasi-continuum Model.The Journal of membrane biology · 2015Article
- Fractal globules: a new approach to artificial molecular machines.Biophysical journal · 2014Article
- Two-dimensional strain-hardening membrane model for large deformation behavior of multiple red blood cells in high shear conditions.Theoretical biology & medical modelling · 2014Article
- Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation.PloS one · 2014Article
- Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease.Soft matter · 2013Article
- Mechanics of microtubules: effects of protofilament orientation.Biophysical journal · 2010Article
- Nanomechanics of multiple units in the erythrocyte membrane skeletal network.Annals of biomedical engineering · 2010Article
- Shapes of Red Blood Cells: Comparison of 3D Confocal Images with the Bilayer-Couple Model.Cellular and molecular bioengineering · 2010Article
- Spectrin folding versus unfolding reactions and RBC membrane stiffness.Biophysical journal · 2008Article
- Propagation of mechanical stress through the actin cytoskeleton toward focal adhesions: model and experiment.Biophysical journal · 2008Article
- Cytoskeletal dynamics of human erythrocyte.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- A prestressed cable network model of the adherent cell cytoskeleton.Biophysical journal · 2003Article
- Determination of cellular strains by combined atomic force microscopy and finite element modeling.Biophysical journal · 2002Article
- Coupled multi-component systems: A simple membrane model.Journal of biological physics · 2002Article
- Direct measurement of the area expansion and shear moduli of the human red blood cell membrane skeleton.Biophysical journal · 2001Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A finite element network model has been developed to predict the macroscopic elastic shear modulus and the area expansion modulus of the red blood cell (RBC) membrane skeleton on the basis of its microstructure. The topological organization of connections between spectrin molecules is represented by the edges of a random Delaunay triangulation, and the elasticity of an individual spectrin molecule is represented by the spring constant, K, for a linear spring element. The model network is subjected to deformations by prescribing nodal displacements on the boundary. The positions of internal nodes are computed by the finite element program. The average response of the network is used to compute the shear modulus (mu) and area expansion modulus (kappa) for the corresponding effective continuum. For networks with a moderate degree of randomness, this model predicts mu/K = 0.45 and kappa/K = 0.90 in small deformations. These results are consistent with previous computational models and experimental estimates of the ratio mu/kappa. This model also predicts that the elastic moduli vary by 20% or more in networks with varying degrees of randomness. In large deformations, mu increases as a cubic function of the extension ratio lambda 1, with mu/K = 0.62 when lambda 1 = 1.5.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.