ArticleThe Journal of cell biology1996
Isolation and characterization of a Drosophila gene essential for early embryonic development and formation of cortical cleavage furrows.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization.Seminars in cell & developmental biology · 2023Review
- DNA Methylation Is Correlated with Gene Expression during Diapause Termination of Early Embryonic Development in the Silkworm (International journal of molecular sciences · 2020Article
- Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression.ACS synthetic biology · 2014Article
- Maternal germline-specific genes in the Asian malaria mosquito Anopheles stephensi: characterization and application for disease control.G3 (Bethesda, Md.) · 2014Article
- A synthetic gene drive system for local, reversible modification and suppression of insect populations.Current biology : CB · 2013Article
- Engineering the genomes of wild insect populations: challenges, and opportunities provided by synthetic Medea selfish genetic elements.Journal of insect physiology · 2010Review
- Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development.Developmental biology · 2008Article
- Seizure suppression by top1 mutations in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms.BMC genomics · 2007Article
- The epsilon-subunit of mitochondrial ATP synthase is required for normal spindle orientation during the Drosophila embryonic divisions.Genetics · 2005Article
- A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila.Molecular biology of the cell · 2005Article
- Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11.The Journal of cell biology · 2003Article
- Dystrophins and dystrobrevins.Genome biology · 2001Review
- Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila, is membrane associated and hyperphosphorylated.Molecular biology of the cell · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have isolated a new female sterile mutant from Drosophila melanogaster, which arrests the embryonic development during the transition from syncytial to cellular blastoderm. Cytological analysis of the mutant embryos indicates that pseudocleavage furrows in the syncytial blastoderm are abnormal but not completely disrupted. However, cleavage furrows during cellularization are totally disorganized, and no embryos can develop beyond this stage. Consistent with this observation, the expression of this gene peaks around the cellular blastoderm and not in any later developmental stages. Based on immunofluorescence experiments, the protein product of this gene is localized in both pseudocleavage furrows at the syncytial blastoderm and in the cleavage furrows during the cellularization stage. Sequence homology analysis demonstrates a modest, but statistically significant, similarity of this protein with the carboxyl-terminal domains of dystrophin and a family of proteins collectively known as apodystrophins. It is possible that this protein may play an essential role in organizing and maintaining a specialized cytoskeletal structure, a function also suggested for dystrophin and apodystrophins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.