ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology1996
Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
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- Canine Myocytes Represent a Good Model for Human Ventricular Cells Regarding Their Electrophysiological Properties.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Frequency-dependent effects of omecamtiv mecarbil on cell shortening of isolated canine ventricular cardiomyocytes.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- I-Wire Heart-on-a-Chip I: Three-dimensional cardiac tissue constructs for physiology and pharmacology.Acta biomaterialia · 2017Article
- Noninvasive evaluation of left ventricular force-frequency relationships by measuring carotid arterial wave intensity during exercise stress.Journal of medical ultrasonics (2001) · 2015Article
- Species-dependent adaptation of the cardiac Na+/K+ pump kinetics to the intracellular Na+ concentration.The Journal of physiology · 2014Article
- Acute effects of nonexcitatory electrical stimulation during systole in isolated cardiac myocytes and perfused heart.Physiological reports · 2014Article
- Article
- Toward an integrative computational model of the Guinea pig cardiac myocyte.Frontiers in physiology · 2012Article
- A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research.The international journal of cardiovascular imaging · 2009Article
- Na(+)/Ca(2+) exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart.British journal of pharmacology · 2008Article
- A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte.Biophysical journal · 2006Article
- Age and gender differences in excitation-contraction coupling of the rat ventricle.The Journal of physiology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of action potential duration and elevated cytosolic sodium concentration on the force-frequency relationship in isolated rabbit, guinea pig and rat papillary muscle preparations was studied. Shortening of action potential duration in guinea pig and rabbit from 150-200 ms to values characteristic of rat (20-40 ms), using the K(ATP) channel activator levkromakalim (15 mumol.l-1), markedly reduced the force of contraction and converted the positive force-frequency relationship into negative one at longer pacing cycle lengths. This conversion was greatly enhanced in the presence of acetylstrophanthidin (0.2-1 mumol.l-1), an inhibitor of the Na-K pump. Acetylstrophanthidin (1 mumol.l-1) alone, however, had no effect on the force-frequency relationship. Prolongation of action potential duration in rat with inhibitors of cardiac K channels (4-aminopyridine [10 mmol.l-1] plus tetraethylammonium [2 mmol.l-1) increased the force of contraction and abolished the negative force-frequency relationship observed in rat at longer pacing-cycle lengths. It is concluded that both action potential duration and cytosolic sodium concentration are major determinants of the force-frequency relationship in mammalian myocardium.
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