ReviewPflugers Archiv : European journal of physiology1996
Mechanisms responsible for quantal Ca2+ release from inositol trisphosphate-sensitive calcium stores.
Review in Pflugers Archiv : European journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Computational properties of mitochondria in T cell activation and fate.Open biology · 2016Review
- Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating.The Journal of general physiology · 2012Article
- Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels.Biophysical journal · 2010Article
- Regulation of IP(3)R Channel Gating by Ca(2+) and Ca(2+) Binding Proteins.Current topics in membranes · 2010Article
- Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.Biochimica et biophysica acta · 2009Review
- Inositol trisphosphate receptor Ca2+ release channels.Physiological reviews · 2007Review
- Cellular and molecular mechanisms regulating vascular tone. Part 1: basic mechanisms controlling cytosolic Ca2+ concentration and the Ca2+-dependent regulation of vascular tone.Journal of anesthesia · 2007Review
- Reaction diffusion modeling of calcium dynamics with realistic ER geometry.Biophysical journal · 2006Article
- Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal [corrected] Ca2+release.The Journal of physiology · 2006Article
- Functional properties of Drosophila inositol trisphosphate receptors.The Biochemical journal · 2001Article
- Phasic characteristic of elementary Ca(2+) release sites underlies quantal responses to IP(3).The EMBO journal · 2000Article
- Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization.The Biochemical journal · 2000Article
- Focal agonist stimulation results in spatially restricted Ca2+ release and capacitative Ca2+ entry in bovine vascular endothelial cells.The Journal of physiology · 1999Article
- Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Permissive role of cAMP in the oscillatory Ca2+ response to inositol 1,4,5-trisphosphate in rat hepatocytes.The Biochemical journal · 1998Article
- Incremental Ca2+ mobilization by inositol trisphosphate receptors is unlikely to be mediated by their desensitization or regulation by luminal or cytosolic Ca2+.The Biochemical journal · 1997Article
- Effect of adenine nucleotides on myo-inositol-1,4,5-trisphosphate-induced calcium release.The Biochemical journal · 1997Article
- Imaging the hierarchical Ca2+ signalling system in HeLa cells.The Journal of physiology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of cells by hormones, growth factors or neurotransmitters leads to an increased production of inositol trisphosphate (InsP3) and, after activation of the InsP3 receptor (InsP3R), to Ca2+ release from intracellular Ca2+ stores. The release of intracellular Ca2+ is characterised by a graded response when submaximal doses of agonists are used. The basic phenomenon, called "quantal Ca2+ release", is that even the maintained presence of a submaximal dose of agonist or of InsP3 for long time periods (up to 20 min) provokes only a partial release of Ca2+. This partial, or quantal, release phenomenon is due to the fact that the initially very rapid InsP3-induced Ca2+ release eventually develops into a much slower release phase. Physiologically, quantal release allows the Ca2+ stores to function as increment detectors and to induce local Ca2+ responses. The basic mechanism for quantal release of Ca2+ is presently not known. Possible mechanisms to explain the quantal behaviour of InsP3- induced Ca2+ release include the presence of InsP3Rs with varying sensitivities for InsP3, heterogeneous InsP3R distribution, intrinsic inactivation of the InsP3Rs, and regulation of the InsP3Rs by Ca2+ store content. This article reviews critically the evidence for the various mechanisms and evaluates their functional importance. A Ca2+-mediated conformational change of the InsP3R is most likely the key feature of the mechanism for quantal Ca2+ release, but the exact mode of operation remains unclear. It should also be pointed out that in intact cells more than one mechanism can be involved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.