ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1996
Oligomerization of uridine phosphorimidazolides on montmorillonite: a model for the prebiotic synthesis of RNA on minerals.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 55 citations in OpenAlex.
- Origins of life: first came evolutionary dynamics.QRB discovery · 2023Review
- Review
- Foldamer hypothesis for the growth and sequence differentiation of prebiotic polymers.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The origins of the RNA world.Cold Spring Harbor perspectives in biology · 2012Review
- Homochiral selectivity in RNA synthesis: montmorillonite-catalyzed quaternary reactions of D, L-purine with D, L- pyrimidine nucleotides.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Article
- Montmorillonite-catalysed formation of RNA oligomers: the possible role of catalysis in the origins of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Article
- The RNA world on ice: a new scenario for the emergence of RNA information.Journal of molecular evolution · 2005Review
- Emergence of a dual-catalytic RNA with metal-specific cleavage and ligase activities: the spandrels of RNA evolution.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Non-enzymatic, template-directed ligation of 2'-5' oligoribonucleotides. Joining of a template and a ligator strand.Nucleic acids research · 1998Article
- Biochemical evolution. I. Polymerization On internal, organophilic silica surfaces of dealuminated zeolites and feldspars.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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4 authors at 1 institution in 1 country.
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Abstract
The 5'-phosphorimidazolide of uridine reacts on Na(+)-montmorillonite 22A in aqueous solution to give oligomers as long as 7 mers. The maximum chain length increases to 9 mers and the overall oligomer yield increases when 9:1 ImpU, A5' ppA mixtures react under the same conditions. The oligomer yield and maximum chain length decreases with the structure of the added pyrophosphate in the order A5' ppA > A5' ppU > U5' ppU. Structure analysis of individual oligomer fractions was performed by selective enzymatic hydrolyses followed by HPLC analysis of the products. The regioselectivity for 3',5'-bond formation is 80-90% in the 9:1 ImpU, A5' ppA reaction, a percentage comparable to that observed in the 9:1 ImpA, A5' ppA reaction. Oligomerization of ImpU is inhibited by addition of dA5' ppdA, and MeppA. No oligomers containing A5' ppU were products of the 9:1 ImpU,A5' ppA reaction, a finding consistent with the simple addition of the ImpU to the A5' ppA and not the rearrangement of an ImpU-A5' ppA adduct. Concentrations of lysine or arginine which were close to that of the ImpU did not inhibit oligomer formation. Treatment of Na(+)-montmorillonite with 1 M arginine yielded arginine-montmorillonite, an amino acid-mineral adduct which did not catalyze ImpU oligomerization. Neither the 4-9 mers formed in the 9:1 ImpU, A5' ppA reaction nor the 4-9 mers formed by the base hydrolysis of poly(U) served as templates for the formation of oligo(A)s.
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