ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Electrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 116 citations in OpenAlex.
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Organization and Plasticity of Sodium Channel Expression in the Mouse Olfactory and Vomeronasal Epithelia.Frontiers in neuroanatomy · 2017Article
- In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ.Journal of visualized experiments : JoVE · 2016Article
- Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons.The Journal of general physiology · 2015Article
- Extracellular pH regulates excitability of vomeronasal sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ.Frontiers in neuroanatomy · 2014Article
- Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents.Journal of neurophysiology · 2012Article
- Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.Nature neuroscience · 2012Article
- Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons.The Journal of general physiology · 2012Article
- Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons.Nature communications · 2011Article
- The rodent accessory olfactory system.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2010Review
- Distinct signals conveyed by pheromone concentrations to the mouse vomeronasal organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- TRPM5-expressing microvillous cells in the main olfactory epithelium.BMC neuroscience · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism of sensory transduction in chemosensory neurons of the vomeronasal organ (VNO) is not known. Based on molecular data, it is likely to be different from that mediating sensory transduction in the main olfactory system. To begin to understand this system, we have characterized the electrophysiological properties of dissociated mouse VNO neurons with patch-clamp recording. Sensory neurons were distinguished from nonsensory neurons by the presence of a dendrite, by immunoreactivity for olfactory marker protein, and by the firing of action potentials. The resting potential of VNO neurons was approximately -60 mV, and the average input resistance was 3 Gomega. Current injections as small as 1-2 pA elicited steady trains of action potentials that showed no sign of elicited steady trains of action potentials that showed no sign of adaptation during a 2 sec stimulus duration. The voltage-gated conductances in VNO neurons are distinct from those in olfactory neurons. The Na+ current is composed of two components; the major component was TTX-sensitive (Ki = 3.6 nM). The outward K+ current activates at -30 mV with kinetics 10 times slower than for K+ currents in olfactory neurons. The Ca2+ current is composed of at least two components: an L-type current and a T-type current that activates at -60 mV and is not found in olfactory neurons. We find no evidence for cyclic nucleotide-gated channels in VNO neurons under a variety of experimental conditions, including those that produced large responses in mouse olfactory neurons, which is further evidence for a novel transduction pathway.
Indexed as
Identifiers
8764651PMC6579035W2151100675What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.