ArticleJournal of virology1996
Proteasome complex as a potential cellular target of hepatitis B virus X protein.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 169 citations in OpenAlex.
- Identification of novel HLA class I-restricted hepatitis B virus peptides and their modulation by peptide editor TAPBPR.Frontiers in immunology · 2026Article
- Viral manipulation of the HLA class I antigen processing and presentation pathway.Frontiers in immunology · 2025Review
- Human Viral Oncoproteins and Ubiquitin-Proteasome System.Global medical genetics · 2024Review
- The role of proteasomes in tumorigenesis.Genes & diseases · 2024Review
- PreS1BP mediates inhibition of Hepatitis B virus replication by promoting HBx protein degradation.Virus research · 2024Article
- Pan-caner analysis identifies PSMA7 as a targets for amplification at 20q13.33 in tumorigenesis.Scientific reports · 2024Article
- Pathogenicity and virulence of Hepatitis B virus.Virulence · 2022Review
- HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression.Journal of biomedical science · 2021Article
- The Hepatitis B Virus Interactome: A Comprehensive Overview.Frontiers in microbiology · 2021Review
- Overexpression of PSMA7 predicts poor prognosis in patients with gastric cancer.Oncology letters · 2019Article
- Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation.Emerging microbes & infections · 2019Article
- The transcription levels and prognostic values of seven proteasome alpha subunits in human cancers.Oncotarget · 2017Article
- Hepatitis B virus X protein in liver tumor microenvironment.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress.Oncotarget · 2016Article
- Review
- PSMA7 inhibits the tumorigenicity of A549 human lung adenocarcinoma cells.Molecular and cellular biochemistry · 2012Article
- Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?Cancer research · 2011Article
- Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo.Journal of virology · 2010Article
- Interactions of SARS coronavirus nucleocapsid protein with the host cell proteasome subunit p42.Virology journal · 2010Article
- Bortezomib inhibits hepatitis B virus replication in transgenic mice.Antimicrobial agents and chemotherapy · 2010Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although the biological importance of hepatitis B virus X protein (HBX) in the life cycle of hepatitis B virus has been well established, the cellular and molecular basis of its function remains largely undefined. Despite the association of multiple activities with HBX, none of them appear to provide a unifying hypothesis regarding the true biological function of HBX. Identification and characterization of cellular targets of HBX remain an essential goal in the elucidation of the molecular mechanisms of HBX. Using the Saccharomyces cerevisiae two-hybrid system, we have identified and characterized a novel subunit of the proteasome complex (XAPC7) that interacts specifically with HBX. We also showed that HBX binds specifically to XAPC7 in vitro. Mutagenesis studies have defined the domains of interaction to be critical for the function of HBX. Furthermore, overexpression of XAPC7 appeared to activate transcription by itself and antisense expression of XAPC7 was able to block transactivation by HBX. Therefore, the proteasome complex is possibly a functional target of HBX in cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.